N-(4,5-dibromothiazol-2-yl)-2,2-dimethylpropanamide | 840493-85-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(4,5-dibromothiazol-2-yl)-2,2-dimethylpropanamide
• 英文别名: N-(4,5-dibromo-1,3-thiazol-2-yl)-2,2-dimethylpropanamide
• CAS: 840493-85-8
• 化学式: C₈H₁₀Br₂N₂OS
• 分子量: 342.054
• InChiKey: OIYHCJQMVKFSEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  70.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,2-dimethyl-N-thiazol-2-ylpropionamide 在 溴 、 三乙胺 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 反应 3.0h， 生成 N-(4,5-dibromothiazol-2-yl)-2,2-dimethylpropanamide
  参考文献：
  名称：

  Investigations of the Halogen Dance Reaction on N-Substituted 2-Thiazolamines

  摘要：

  DIAGRAMThe halogen dance (HD) reaction on various 2-thiazolamine systems was investigated providing an easy access to a series of 5-substituted 4-bromo-2-thiazolamine derivatives. We could Show that HD is a very favored process for the investigated systems and that prevention of HD is only possible when optimized reaction conditions and selected electrophiles are applied.

  DOI：

  10.1021/jo0484326

文献信息

• Investigations of the Halogen Dance Reaction on N-Substituted 2-Thiazolamines
  作者：Peter Stanetty、Michael Schnürch、Kurt Mereiter、Marko D. Mihovilovic

  DOI：10.1021/jo0484326

  日期：2005.1.1

  DIAGRAMThe halogen dance (HD) reaction on various 2-thiazolamine systems was investigated providing an easy access to a series of 5-substituted 4-bromo-2-thiazolamine derivatives. We could Show that HD is a very favored process for the investigated systems and that prevention of HD is only possible when optimized reaction conditions and selected electrophiles are applied.