3-methoxy-benzaldehyde-(4-phenyl thiosemicarbazone) | 74959-59-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-methoxy-benzaldehyde-(4-phenyl thiosemicarbazone)
• 英文别名: 3-Methoxy-benzaldehyd-(4-phenyl-thiosemicarbazon)；4-Phenyl-1-(3-methoxy-benzal)-thiosemicarbazid；3-Methoxybenzaldehyde N-phenylthiosemicarbazone；1-[(E)-(3-methoxyphenyl)methylideneamino]-3-phenylthiourea
• CAS: 74959-59-4
• 化学式: C₁₅H₁₅N₃OS
• 分子量: 285.37
• InChiKey: DJCCIBUIWLJLJR-LFIBNONCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  77.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-methoxy-benzaldehyde-(4-phenyl thiosemicarbazone) 、 三氯化铁 以50%的产率得到
  参考文献：
  名称：

  MARTVON A.; STANKOVSKY S.; UHER M., CHEM. 2VESTI, 1980, 34, NO 1, 118-124

  摘要：

  DOI：
• 作为产物：
  描述：

  3-甲氧基苯甲醛 、 4-苯基-3-硫代氨基脲 在 溶剂黄146 作用下， 以 乙醇 、 水 为溶剂， 以94%的产率得到3-methoxy-benzaldehyde-(4-phenyl thiosemicarbazone)
  参考文献：
  名称：

  Synthesis, anti-Toxoplasma gondii and antimicrobial activities of benzaldehyde 4-phenyl-3-thiosemicarbazones and 2-[(phenylmethylene)hydrazono]-4-oxo-3-phenyl-5-thiazolidineacetic acids

  摘要：

  In the present communication, a new series of 2-[(phenylmethylene)hydrazono]-4-oxo-3-phenyl-5-thiazolidineacetic acids (2a-p) have been synthesized. Benzaldehyde 4-phenyl-3-thiosemicarbazones substituted (la-p) were also obtained and used as intermediate to give the title compounds. All synthesized compounds were characterized by IR, H-1 and (13) C NMR. The in vitro anti-Toxoplasma gondii activity of la-p and 2a-p was evaluated. The 4-thiazolidinones (2a-p) were screened for their ill vitro antimicrobial activity. For anti-Toxoplasma gondii activity, in general, all compounds promoted decreases in the percentage of infected cells leading to parasite elimination. These effects on intracellular parasites also caused a decrease in the mean number of tachyzoites. In addition, most of the 4-thiazolidinones showed more effective toxicity against intracellular parasites, with IC50 values ranging from 0.05 to 1 mM. According to results of antimicrobial activity, compounds 2f, 21, and 2p showed best activity against Mycobacterium luteus, 2c was more active against Mycobacterium tuberculosis, and 2g, 21, and 2n showed same activity as nistatin (standard drug) against Candida sp. (4249). (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.09.025

文献信息

• Negotiating the Public Sphere through Private Correspondence: A Woman’s Letters of Liberty in Eighteenth-Century Germany
  作者：Melanie Archangeli

  DOI：10.1111/1468-0483.00178

  日期：2000.10

  The pivotal role played by letters in eighteenth‐century German literary, cultural and everyday life has long been recognised. In contrast to earlier times, many of the letters written in the eighteenth century were composed by women, and their correspondence provides modern scholars with a rich source of information abour the process of communication in the intimate, private and public spheres. The linited correspondence of Charlotte von Hezel, the first woman in Germany to edit a periodical under her own name, is of particular interest because it offers one of the few examaples of a woman corresponding with men for professional, not personal reasons. In addition, Hezel, not her male correspondents, represents the voice of authority within the area of activity being discussed: the publication of her magazine. Hezel’s self‐assurance is remarkable for a German woman of the time, and her letters demonstrate a liberating process of communication that allowed individuals hingered by gender, educational background or social status to debate contemporary issues and exchange serviced as they negotiated their entry into the public sphere.
• Synthesis, anti-Toxoplasma gondii and antimicrobial activities of benzaldehyde 4-phenyl-3-thiosemicarbazones and 2-[(phenylmethylene)hydrazono]-4-oxo-3-phenyl-5-thiazolidineacetic acids
  作者：Thiago M. de Aquino、André P. Liesen、Rosa E.A. da Silva、Vânia T. Lima、Cristiane S. Carvalho、Antônio R. de Faria、Janete M. de Araújo、José G. de Lima、Antonio J. Alves、Edésio J.T. de Melo、Alexandre J.S. Góes

  DOI：10.1016/j.bmc.2007.09.025

  日期：2008.1

  In the present communication, a new series of 2-[(phenylmethylene)hydrazono]-4-oxo-3-phenyl-5-thiazolidineacetic acids (2a-p) have been synthesized. Benzaldehyde 4-phenyl-3-thiosemicarbazones substituted (la-p) were also obtained and used as intermediate to give the title compounds. All synthesized compounds were characterized by IR, H-1 and (13) C NMR. The in vitro anti-Toxoplasma gondii activity of la-p and 2a-p was evaluated. The 4-thiazolidinones (2a-p) were screened for their ill vitro antimicrobial activity. For anti-Toxoplasma gondii activity, in general, all compounds promoted decreases in the percentage of infected cells leading to parasite elimination. These effects on intracellular parasites also caused a decrease in the mean number of tachyzoites. In addition, most of the 4-thiazolidinones showed more effective toxicity against intracellular parasites, with IC50 values ranging from 0.05 to 1 mM. According to results of antimicrobial activity, compounds 2f, 21, and 2p showed best activity against Mycobacterium luteus, 2c was more active against Mycobacterium tuberculosis, and 2g, 21, and 2n showed same activity as nistatin (standard drug) against Candida sp. (4249). (c) 2007 Elsevier Ltd. All rights reserved.
• MARTVON A.; STANKOVSKY S.; UHER M., CHEM. 2VESTI, 1980, 34, NO 1, 118-124
  作者：MARTVON A.、 STANKOVSKY S.、 UHER M.

  DOI：——

  日期：——