2-ethenylcyclodecanone | 80533-40-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-ethenylcyclodecanone
• 英文别名: 2-vinylcyclodecanone；2-Ethenylcyclodecan-1-one
• CAS: 80533-40-0
• 化学式: C₁₂H₂₀O
• 分子量: 180.29
• InChiKey: PIEPVVMRXHSETR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  环癸酮 在 甲基磺酰氯 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 生成 2-ethenylcyclodecanone
  参考文献：
  名称：

  .alpha. Vinylation of ketones. A general method using (phenylseleno)acetaldehyde

  摘要：

  DOI：

  10.1021/jo00348a005

文献信息

• Process for producing 2-vinylcyclododecanone
  申请人：——

  公开号：US20020038056A1

  公开（公告）日：2002-03-28

  A process for producing 2-vinylcyclododecanone, the process comprising isomerizing 2-ethylidenecyclododecanone represented by the following formula (1): 1 wherein the wavy line signifies that the double bond is a Z-isomer, an E-isomer or a mixture of an E-isomer and a Z-isomer; in the presence of a catalyst and separating 2-vinylcyclododecanone represented by the following formula (2) from the reaction product by fractionation: 2

  一种制备2-乙烯基环十二酮的方法，该方法包括在催化剂存在下异构化以下式(1)所示的2-乙烯基环十二酮：其中波浪线表示双键为Z异构体、E异构体或E异构体和Z异构体的混合物；通过分馏从反应产物中分离以下式(2)所示的2-乙烯基环十二酮。
• Process and apparatus for production of 5-cyclohexadecen-1-one
  申请人：Takasago International Corporation

  公开号：EP0955285A1

  公开（公告）日：1999-11-10

  This invention relates to a process for producing 5-cyclohexadecen-1-one continuously from 1,2-divinylcyclododecanol in a short time in an efficient manner without no side reaction. In the process, 1,2-divinylcyclododecanol as starting material is supplied from a raw material container 1 by a fixed delivery pump 2 to a flash unit 3 which is vacuumed to 5 mm Hg (666.5 Pa) or less by a vacuum pump 8 and is heated and 1,2-divinylcyclododecanol which is flashed in the flash unit is supplied to a reactor 4 which is heated to 400 to 650°C and vacuumed to 5 mm Hg (666.5 Pa) or less whereby 1,2-divinylcyclododecanol is converted into 5-cyclohexadecen-1-one. The reaction product is discharged from the top of the reactor and is cooled to recover the objective 5-cyclohexadecen-1-one in the recovery container 6. The reduction in the pressure of the apparatus is preferably performed by a vacuum pump 8 via a hydrochloric acid trap 7 comprising, for example, sodium methylate/methanol cooled to -78 to -100°C.

  本发明涉及一种以 1,2-二乙烯基环十二醇为原料在短时间内连续生产 5-环 十六烯-1-酮的工艺，生产过程高效且无副作用。在该工艺中，1,2-二乙烯基环十二醇作为起始原料由固定输送泵 2 从原料容器 1 输送到闪蒸装置 3，闪蒸装置 3 通过真空泵抽真空至 5 毫米汞柱（666.闪蒸单元中闪蒸的 1，2-二乙烯基环十二醇被送入反应器 4，反应器 4 被加热至 400 至 650°C，真空度为 5 mm Hg (666.5 Pa) 或更低，1，2-二乙烯基环十二醇由此转化为 5-环十六烯-1-酮。反应产物从反应器顶部排出，冷却后在回收容器 6 中回收目标 5-环十六烯-1-酮。设备的减压最好由真空泵 8 通过盐酸捕集器 7 来完成，盐酸捕集器 7 包括冷却至 -78 至 -100°C 的甲酸钠/甲醇等。
• Process for producing 2-vinylcyclododecanone.
  申请人：Takasago International Corporation

  公开号：EP1162189A2

  公开（公告）日：2001-12-12

  A process for producing 2-vinylcyclododecanone, the process comprising isomerizing 2-ethylidenecyclododecanone represented by the following formula (1): wherein the wave line shows that the double bond is a Z-isomer, an E-isomer or a mixture of an E-isomer and a Z-isomer; in the presence of a catalyst and separating 2-vinylcyclododecanone represented by the following formula (2) from the reaction product by fractionation:    2-Vinylcyclododecanone can be produced using 2-ethylidenecyclododecanone, which can be manufactured simply from cyclododecanone in a high yield through no chlorination, without using any solvent having safety problems in a high yield by using a simple process involving neither washing nor solvent recovery.

  一种生产 2-乙烯基环十二酮的工艺，该工艺包括将下式(1)代表的 2-亚乙基环十二酮异构化： 其中波浪线表示双键是 Z-异构体、E-异构体或 E-异构体和 Z-异构体的混合物；在催化剂存在下，通过分馏从反应产物中分离出下式（2）代表的 2-乙烯基环十二酮： 可以使用 2-亚乙基环十二酮生产 2-乙烯基环十二酮，这种环十二酮可以简单地从环 十二酮中生产出来，无需氯化，不使用任何有安全问题的溶剂，采用简单的工艺，既不 涉及洗涤，也不涉及溶剂回收，产量很高。
• CLIVE, D. L. J.;RUSSELL, C. G.;SURI, S. CHANDER, J. ORG. CHEM., 1982, 47, N 9, 1639-1641
  作者：CLIVE, D. L. J.、RUSSELL, C. G.、SURI, S. CHANDER

  DOI：——

  日期：——
• US6548711B2
  申请人：——

  公开号：US6548711B2

  公开（公告）日：2003-04-15