({4-{2-[2-(2-Amino-ethoxy)-ethoxy]-ethoxy}-6-[(bis-ethoxycarbonylmethyl-amino)-methyl]-pyridin-2-ylmethyl}-ethoxycarbonylmethyl-amino)-acetic acid ethyl ester | 530151-67-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ({4-{2-[2-(2-Amino-ethoxy)-ethoxy]-ethoxy}-6-[(bis-ethoxycarbonylmethyl-amino)-methyl]-pyridin-2-ylmethyl}-ethoxycarbonylmethyl-amino)-acetic acid ethyl ester
• 英文别名: Ethyl 2-[[4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-6-[[bis(2-ethoxy-2-oxoethyl)amino]methyl]pyridin-2-yl]methyl-(2-ethoxy-2-oxoethyl)amino]acetate
• CAS: 530151-67-8
• 化学式: C₂₉H₄₈N₄O₁₁
• 分子量: 628.72
• InChiKey: RWBILTKNKOVZPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  44
• 可旋转键数：
  29
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  178
• 氢给体数：
  1
• 氢受体数：
  15

反应信息

• 作为反应物：
  描述：

  ({4-{2-[2-(2-Amino-ethoxy)-ethoxy]-ethoxy}-6-[(bis-ethoxycarbonylmethyl-amino)-methyl]-pyridin-2-ylmethyl}-ethoxycarbonylmethyl-amino)-acetic acid ethyl ester 在 lithium hydroxide 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 氯仿 为溶剂， 反应 27.0h， 生成 {[6-[(Bis-carboxymethyl-amino)-methyl]-4-(2-{2-[2-(2,3-bis-hexadecanoylamino-propionylamino)-ethoxy]-ethoxy}-ethoxy)-pyridin-2-ylmethyl]-carboxymethyl-amino}-acetic acid
  参考文献：
  名称：

  Synthesis of Metal-Chelating Lipids to Sensitize Lanthanide Ions

  摘要：

  Sensitization of lanthanide ions is important for lanthanide ion-based assays and sensing. To the best of our knowledge, there are very few reports of lanthanide ion sensitization after it is incorporated into the liposome surface. This paper describes the syntheses of several saturated and polymerizable metal-chelating lipids based on chelidamic acid. The lipids are synthesized either from (S)-ornithine or racemic 2,3-diaminopropanoic acid. These lipids as well as polymerized liposomes incorporating these lipids sensitize lanthanide ions. Liposomes from the lipid 18-Eu3+ provided a probe that relies not only on the emission wavelengths of Eu3+ but also on a reproducible lifetime that can be used for protein identification.

  DOI：

  10.1021/jo026833k
• 作为产物：
  描述：

  叠氮-三聚乙二醇-丙炔基 在 palladium on activated charcoal 盐酸 、 sodium tetrahydroborate 、 氢气 、 三溴化磷 、 potassium carbonate 、 calcium chloride 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 68.0h， 生成 ({4-{2-[2-(2-Amino-ethoxy)-ethoxy]-ethoxy}-6-[(bis-ethoxycarbonylmethyl-amino)-methyl]-pyridin-2-ylmethyl}-ethoxycarbonylmethyl-amino)-acetic acid ethyl ester
  参考文献：
  名称：

  Synthesis of Metal-Chelating Lipids to Sensitize Lanthanide Ions

  摘要：

  Sensitization of lanthanide ions is important for lanthanide ion-based assays and sensing. To the best of our knowledge, there are very few reports of lanthanide ion sensitization after it is incorporated into the liposome surface. This paper describes the syntheses of several saturated and polymerizable metal-chelating lipids based on chelidamic acid. The lipids are synthesized either from (S)-ornithine or racemic 2,3-diaminopropanoic acid. These lipids as well as polymerized liposomes incorporating these lipids sensitize lanthanide ions. Liposomes from the lipid 18-Eu3+ provided a probe that relies not only on the emission wavelengths of Eu3+ but also on a reproducible lifetime that can be used for protein identification.

  DOI：

  10.1021/jo026833k