6-O-methyl-4''-O-(2-O-acetyl-β-D-glucopyranosyl)-erythromycin A | 1252559-71-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-O-methyl-4''-O-(2-O-acetyl-β-D-glucopyranosyl)-erythromycin A
• 英文别名: [(2S,3R,4S,5S,6R)-2-[(2S,3S,4R,6R)-6-[[(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-4-yl]oxy]-4-methoxy-2,4-dimethyloxan-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl] acetate
• CAS: 1252559-71-9
• 化学式: C₄₆H₈₁NO₁₉
• 分子量: 952.144
• InChiKey: LXXKDRULOOKAOM-ZYSNJSESSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  66
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  268
• 氢给体数：
  6
• 氢受体数：
  20

反应信息

• 作为产物：
  描述：

  2'-O-acetyl-6-O-methyl-4''-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-erythromycin A 在 potassium carbonate 作用下， 以 甲醇 为溶剂， 反应 12.0h， 以33%的产率得到6-O-methyl-4''-O-(β-D-glucopyranosyl)-erythromycin A
  参考文献：
  名称：

  A new series of macrolide derivatives with 4″-O-saccharide substituents

  摘要：

  A series of novel derivatives of macrolide with 4 ''-O-mono- or disaccharides were synthesized. The corresponding glycosyl trichloroacetimidates were used as the donors in the glycosylations. The in vitro antibacterial activities of 7a-f and 13-16 against a panel of susceptible and resistant pathogens were tested. The modification of 4 ''-O-mono- or disaccharides may lead to the understanding of interaction of the macrolide and the bacterial ribosome. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.07.072