Synthetic studies on azadirachtin (Part 3): Asymmetric synthesis of the tricyclic dihydrofuran moiety of azadirachtin
作者:Jun Ishihara、Takehiro Fukuzaki、Akio Murai
DOI:10.1016/s0040-4039(99)00040-4
日期:1999.3
An asymmetric synthesis of the tricyclic dihydrofuran moiety of azadirachtin is reported. The Diels-Alder adduct, which was catalyzed by Evans' chiral Cu-bisoxazoline complex, was easily converted to the tricyclic portion via SmI2 reductive cleavage and selective functionalization.
据报道印za素的三环二氢呋喃部分不对称合成。由埃文斯的手性铜-双恶唑啉配合物催化的狄尔斯-阿尔德加合物易于通过SmI 2还原裂解和选择性功能化转化为三环部分。