pyruvic acid semicarbazone | 2704-30-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: pyruvic acid semicarbazone
• 英文别名: 2-(Carbamoylhydrazinylidene)propanoic acid
• CAS: 2704-30-5
• 化学式: C₄H₇N₃O₃
• mdl: MFCD00462853
• 分子量: 145.118
• InChiKey: MGIAKYQGSBSNMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  pyruvic acid semicarbazone 在 sodium hydroxide 作用下， 以 水 为溶剂， 生成 6-氮杂胸腺嘧啶
  参考文献：
  名称：

  Synthesis and antimicrobial evaluation of 6-azauracil non-nucleosides

  摘要：

  The present study describes synthesis and antimicrobial evaluation of a series of novel 6-azauracil non-nucleosides. Reaction of silylated 6-azauracils with the appropriate chloroethers gave the corresponding non-nucleosides. 1-(Allyloxymethy)6-azauracils and non-nucleosides bearing indanyl, cyclohexenyl, and cyclohexyl moieties were obtained via silylation of 6-azauracils followed by treatment with the appropriate acetals. Selected compounds were tested for their in vitro antimicrobial activity against a panel of standard strains of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. Four compounds showed marked inhibitory activity particularly against the tested Gram-positive bacteria.

  DOI：

  10.1007/s00706-008-0948-7
• 作为产物：
  描述：

  盐酸氨基脲 、 丙酮酸 以 水 为溶剂， 以to obtain 21 g of 2-carbamoylhydrazonopropionic acid having a melting point of 201° C. (decomposed)的产率得到pyruvic acid semicarbazone
  参考文献：
  名称：

  Heat-developable light-sensitive material

  摘要：

  一种热显影彩色感光材料，包括一个支撑体，其上至少含有一层含有新型碱基前体的层。这种热显影彩色感光材料在相对较低的温度和短时间内进行热显影，提供高最大密度和低雾度。

  公开号：

  US04640892A1

文献信息

• Sawhney, G. L.; Baijal, J. S.; Chandra, S., Acta Chimica Academiae Scientiarum Hungaricae, 1981, vol. 108, p. 325 - 332
  作者：Sawhney, G. L.、Baijal, J. S.、Chandra, S.、Pandeya, K. B.

  DOI：——

  日期：——
• Synthesis, characterization and scavenger effects of OH• and O−•2 radicals of lanthanide(III) complexes with pyruvic acid semicarbazone
  作者：Shuyan Yu、Shuangxi Wang、Qinhui Luo、Liufang Wang、Zhouren Peng、Xing Gao

  DOI：10.1016/s0277-5387(00)87189-2

  日期：1993.5

  Complexes of lanthanide chlorides with pyruvic acid semicarbazone (PASH), having the general formula Ln(PAS) 3 . nH2O (where Ln = La-Nd, Sm-Dy, Er, Yb; n = 1-3), have been synthesized and characterized on the basis of elemental analyses, IR spectra and thermal analyses. It has been found that the ligand and its complexes possess scavenger effects on OH. and O2-. radicals.
• The manganese(II) complex of a hydrazone ligand derived from pyruvic acid and semicarbazide—synthesis, properties and crystal structure
  作者：Wang Liufang、Peng Zhouren、Wang Xin、Yu Shuyan、Luo Qinhui、Wang Qi

  DOI：10.1016/s0277-5387(00)84590-8

  日期：1993.1