(E)-1-methoxyheptene | 55373-78-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (E)-1-methoxyheptene
• 英文别名: (E)-1-Methoxyhepten；1t-methoxy-hept-1-ene；(E)-1-methoxyhept-1-ene
• CAS: 55373-78-9
• 化学式: C₈H₁₆O
• 分子量: 128.214
• InChiKey: NDLSEQCVBNTZHF-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (E)-1-methoxyheptene 、 甲基溴化镁 、 三苯基膦 以70%的产率得到
  参考文献：
  名称：

  WENKERT, E.;MICHELOTTI, E. L.;SWINDELL, CH. S.;TINGOLI, M., J. ORG. CHEM., 1984, 49, N 25, 4894-4899

  摘要：

  DOI：
• 作为产物：
  描述：

  trans-3-Chlor-1-methoxy-propen-(1) 、 正丁基锂 生成 (E)-1-methoxyheptene
  参考文献：
  名称：

  HAGEN J. P.; HARRIS J. J.; LAKIN D., J. ORG. CHEM., 52,(1987) N 5, 782-787

  摘要：

  DOI：

文献信息

• Amino alcohol derivatives
  申请人：SANKYO COMPANY, LIMITED

  公开号：US20030236297A1

  公开（公告）日：2003-12-25

  Compounds of formula (I) which exhibit excellent immune suppression activity, pharmacologically acceptable salts thereof, esters thereof or other derivatives: 1 wherein R 1 and R 2 are a hydrogen atom, an amino protecting group; R 3 is a hydrogen atom, a hydroxy protecting group; R 4 is a lower alkyl group; n is an integer from 1 to 6; X is an ethylene group; Y is a C 1 -C 10 alkylene group, a C 1 -C 10 alkylene group substituted with 1 to 3 substituents selected from substituent group a and b; R 5 is an aryl group; R 6 and R 7 are a hydrogen atom, a group selected from substituent group a; with the proviso when R 5 is a hydrogen atom, Y is not a single bond or a straight chain C 1 -C 10 alkylene group.

  式（I）的化合物表现出优异的免疫抑制活性，其药理学上可接受的盐，酯或其他衍生物：其中R1和R2是氢原子，氨基保护基；R3是氢原子，羟基保护基；R4是较低的烷基基团；n是1到6之间的整数；X是乙烯基团；Y是C1-C10烷基基团，带有1到3个从取代基a和b中选择的取代基的C1-C10烷基基团；R5是芳基基团；R6和R7是氢原子，从取代基a中选择的基团；但是当R5是氢原子时，Y不是单键或直链的C1-C10烷基基团。
• Methods and compositions for protecting animals and humans against attack and infestation by arthropod and helminth parasites
  申请人：American Cyanamid Company

  公开号：EP0933027A1

  公开（公告）日：1999-08-04

  The present invention relates to methods and compositions for treating animals and humans, and for controlling, preventing and protecting animals and humans from infestation and infection by arthropod and helminth parasites by administering or applying to the animals, humans or their environment a 1,4-diaryl-2-fluoro-2-butene or 1,4-diaryl-2,3-difluoro-2-butene compound having the structural formula

  本发明涉及用于治疗动物和人类、控制、预防和保护动物和人类免受节肢动物和蠕虫寄生虫侵染和感染的方法和组合物，通过向动物、人类或其环境施用具有结构式的1,4-二芳基-2-氟-2-丁烯或1,4-二芳基-2,3-二氟-2-丁烯化合物。
• Liquid crystalline compounds having a silane diyl group, liquid crystal compositions comprising the same and liquid crystal display devices
  申请人：CHISSO CORPORATION

  公开号：EP1160251A2

  公开（公告）日：2001-12-05

  Liquid crystalline compounds which have large dielectric anisotropy, high electrical insulation properties (high specific resistance or high voltage holding ratio), small temperature dependence, broad liquid crystal phase temperature range, excellent compatibility and low viscosity and which are represented by formula (1) A4 each independently represent 1,4-cyclohexylene,1,4-phenylene, etc.; R1 represents C1-C20 alkyl in which any methylene may be replaced by -O-, etc.; R2 represents halogen, cyano or C1-C10 alkyl in which at least one hydrogen is replaced by halogen; and at least one of Z1, Z2 and Z3 represents -SiH2CH2- or -CH2SiH2-. Further, liquid crystal compositions comprising at least one liquid crystalline compound of formula (1) and liquid crystal display devices composed of the compositions, which can exhibit low threshold voltage, high electrical insulation properties and low viscosity.

  具有大介电各向异性、高电绝缘性能（高比电阻或高耐电压比）、温度依赖性小、液晶相温度范围广、优异的相容性和低粘度的液晶化合物，其化学式为（1）中A4分别独立表示1,4-环己烯基、1,4-苯基等；R1表示C1-C20烷基，其中任何亚甲基可能被-O-等取代；R2表示卤素、氰基或C1-C10烷基，其中至少有一个氢原子被卤素取代；Z1、Z2和Z3中至少有一个表示-SiH2CH2-或-CH2SiH2-。此外，液晶化合物至少包括化学式（1）中的一种液晶化合物的液晶组合物和由该组合物组成的液晶显示器件，可表现出低阈值电压、高电绝缘性能和低粘度。
• Amino alcohol derivatives or phosphonic acid derivatives and pharmaceutical compositions containing these
  申请人：Nishi Takahide

  公开号：US20050043386A1

  公开（公告）日：2005-02-24

  Amino alcohol compounds and phosphonic acid compounds having excellent immunosuppressive activity, pharmacologically acceptable salts thereof and pharmacologically acceptable esters thereof, and pharmaceutical compositions comprising such compounds, the compounds having the following formula: wherein R 1 and R 2 each represent hydrogen, or a protecting group of the amino group; R 3 represents hydrogen, or a protecting group of the hydroxyl group; R 4 represents a lower alkyl group; n is 1 to 6; X represents oxygen or nitrogen, which is unsubstituted or substituted with a lower alkyl group; Y represents ethylene; Z represents a C 1 -C 10 alkylene; R 5 represents an aryl group; and R 6 and R 7 each represents hydrogen; provided that when R 5 represents hydrogen, then Z represents a group other than a single bond or a straight chain C 1 -C 10 alkylene group.

  具有出色的免疫抑制活性的氨基醇化合物和膦酸化合物，其药理学上可接受的盐和药理学上可接受的酯，以及包含这些化合物的制药组合物，其中化合物具有以下式子：其中R1和R2各代表氢，或氨基保护基；R3代表氢，或羟基保护基；R4代表较低的烷基；n为1至6；X代表氧或氮，未取代或取代为较低的烷基；Y代表乙烯；Z代表C1-C10烷基；R5代表芳基；R6和R7各代表氢；但是当R5代表氢时，Z代表除单键或直链C1-C10烷基组以外的一种基团。
• Amino alcohol compounds
  申请人：Nishi Takahide

  公开号：US20070105933A1

  公开（公告）日：2007-05-10

  A method for the preventing a disease selected from the group consisting of rheumatoid arthritis and psoriasis in a mammal, such as a human, in need thereof, which includes administering to the mammal a pharmaceutically effective amount of a compound of formula (Ia) wherein R 1 and R 2 are each hydrogen; R 3 is hydrogen; R 4 is C 1 -C 2 alkyl; n is 2; X is=N-D, wherein D is hydrogen, C 1 -C 4 alkyl or phenyl; Y is ethylene, ethynylene, —CO—CH 2 or phenylene; Z is ethylene or trimethylene; R 5 is an unsubstituted C 3 -C 10 cycloalkyl, an unsubstituted C 6 -C 10 aryl, or a C 3 -C 10 cycloalkyl or C 6 -C 10 aryl substituted with 1 to 3 substituents selected from the group consisting of halogen, lower alkyl, halogeno lower alkyl and lower alkoxy; and R 6 and R 7 are each hydrogen.

  本发明涉及一种用于预防哺乳动物，例如人类，需要预防风湿性关节炎和银屑病等疾病的方法，包括向哺乳动物内部给予化合物（Ia）的药物有效量，其中R1和R2均为氢; R3为氢; R4为C1-C2烷基; n为2; X为=N-D，其中D为氢、C1-C4烷基或苯基; Y为乙烯基、乙炔基、-CO-CH2或苯基; Z为乙烯基或三亚甲基; R5为未取代的C3-C10环烷基、未取代的C6-C10芳基或取代有1-3个取代基的C3-C10环烷基或C6-C10芳基，所述取代基选自卤素、低碳基、卤代低碳基和低烷氧基的群体; R6和R7均为氢。