6-phenyl-15-tosyl-15H-benzo[a]naphtho[1',2':11,12]chryseno[5,6-c]carbazole | 1337901-88-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 6-phenyl-15-tosyl-15H-benzo[a]naphtho[1',2':11,12]chryseno[5,6-c]carbazole
• 英文别名: 10-(4-Methylphenyl)sulfonyl-34-phenyl-10-azadecacyclo[23.16.0.02,18.03,8.09,17.011,16.019,24.026,35.027,32.036,41]hentetraconta-1(25),2(18),3,5,7,9(17),11,13,15,19,21,23,26(35),27,29,31,33,36,38,40-icosaene
• CAS: 1337901-88-8
• 化学式: C₅₃H₃₃NO₂S
• 分子量: 747.917
• InChiKey: YTAFQLNPNBVEBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15.3
• 重原子数：
  57
• 可旋转键数：
  3
• 环数：
  12.0
• sp3杂化的碳原子比例：
  0.02
• 拓扑面积：
  47.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-[(2-ethynylphenyl)ethynyl]aniline 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 二(氰基苯)二氯化钯 、 silver tetrafluoroborate 、 三叔丁基膦 、 氯[2-二环己基(2',4',6'-三异丙基联苯基)膦]金(I) 、 四丁基氟化铵 、 三乙胺 、 二异丙胺 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 72.83h， 生成 6-phenyl-15-tosyl-15H-benzo[a]naphtho[1',2':11,12]chryseno[5,6-c]carbazole
  参考文献：
  名称：

  Gold(I)-Catalyzed Polycyclizations of Polyenyne-Type Anilines Based on Hydroamination and Consecutive Hydroarylation Cascade

  摘要：

  A hydroamination-double hydroarylation cascade using aniline derivatives bearing a trienyne moiety as the substrate was efficiently promoted by a gold(I) catalyst to produce benzo[a]naphtho [2,1-c]carbazole derivatives in good yields. This reaction is applicable to various substituted trienyne-type anilines, including 2,3-diethynylthiophene derivatives. The reaction of anilines bearing a tetraenyne and pentaenyne moiety allows direct construction of highly fused carbazoles by tetra- and pentacyclization, respectively, through hydroamination and consecutive hydroarylation without producing any theoretical waste products from the substrates.

  DOI：

  10.1021/jo2018119