4-((S)-5-{(S)-1-[(S)-1-((S)-5-Benzyloxycarbonylamino-1-carbamoyl-pentylcarbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-5-tert-butoxycarbonylamino-pentylcarbamoyl)-butyric acid | 215512-11-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-((S)-5-{(S)-1-[(S)-1-((S)-5-Benzyloxycarbonylamino-1-carbamoyl-pentylcarbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-5-tert-butoxycarbonylamino-pentylcarbamoyl)-butyric acid
• 英文别名: Boc-Lys(glutaryl)(glutaryl)-Phe-Phe-Lys(Cbz)(Cbz)-NH2；5-[[(5S)-6-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-6-(phenylmethoxycarbonylamino)hexan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-[(2-methylpropan-2-yl)oxycarbonylamino]-6-oxohexyl]amino]-5-oxopentanoic acid
• CAS: 215512-11-1
• 化学式: C₄₈H₆₅N₇O₁₁
• 分子量: 916.084
• InChiKey: NJVGQACTLCKITO-GTKRZRNESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  66
• 可旋转键数：
  31
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  273
• 氢给体数：
  8
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  4-((S)-5-{(S)-1-[(S)-1-((S)-5-Benzyloxycarbonylamino-1-carbamoyl-pentylcarbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-5-tert-butoxycarbonylamino-pentylcarbamoyl)-butyric acid 在 palladium on activated charcoal 氢气 、 碳酸氢钠 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 ((2S,5S,8S,24S)-2,5-Dibenzyl-8-carbamoyl-3,6,14,18,25-pentaoxo-1,4,7,13,19-pentaaza-cyclopentacos-24-yl)-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Synthesis and activity of HIV protease inhibitors

  摘要：

  We report here the synthesis and activity of HIV protease inhibitors. Ln the first stage hydrophobic compounds incorporating a 'carba' bond surrogate or a beta-homologated residue were synthesized. Secondly, we synthesized cyclic compounds in which we incorporated 2-quinoline carboxylic acid in the P3 position and the amino-hydroxyindane moiety in the P'3. The last part of this work was dedicated to a structure/activity study of a peptide substrate. These modifications allowed us to work up the synthesis of new pseudopeptide bonds: amino-amide and hydroxy-amide, Compounds with activity in the micromolar range were actually a starting point for the synthesis of new protease inhibitors. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(98)80043-3
• 作为产物：
  描述：

  Boc-Lys(Fmoc)(Fmoc)-Phe-Phe-Lys(Cbz)(Cbz)-NH2 在 二乙胺 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 4-((S)-5-{(S)-1-[(S)-1-((S)-5-Benzyloxycarbonylamino-1-carbamoyl-pentylcarbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-5-tert-butoxycarbonylamino-pentylcarbamoyl)-butyric acid
  参考文献：
  名称：

  Synthesis and activity of HIV protease inhibitors

  摘要：

  We report here the synthesis and activity of HIV protease inhibitors. Ln the first stage hydrophobic compounds incorporating a 'carba' bond surrogate or a beta-homologated residue were synthesized. Secondly, we synthesized cyclic compounds in which we incorporated 2-quinoline carboxylic acid in the P3 position and the amino-hydroxyindane moiety in the P'3. The last part of this work was dedicated to a structure/activity study of a peptide substrate. These modifications allowed us to work up the synthesis of new pseudopeptide bonds: amino-amide and hydroxy-amide, Compounds with activity in the micromolar range were actually a starting point for the synthesis of new protease inhibitors. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(98)80043-3

文献信息

• Synthesis and activity of HIV protease inhibitors
  作者：Patrick Garrouste、Macek Pawlowski、Thierry Tonnaire、Sames Sicsic、Pascal Dumy、Eve de Rosny、Michèle Reboud-Ravaux、Pierre Fulcrand、Jean Martinez

  DOI：10.1016/s0223-5234(98)80043-3

  日期：1998.6

  We report here the synthesis and activity of HIV protease inhibitors. Ln the first stage hydrophobic compounds incorporating a 'carba' bond surrogate or a beta-homologated residue were synthesized. Secondly, we synthesized cyclic compounds in which we incorporated 2-quinoline carboxylic acid in the P3 position and the amino-hydroxyindane moiety in the P'3. The last part of this work was dedicated to a structure/activity study of a peptide substrate. These modifications allowed us to work up the synthesis of new pseudopeptide bonds: amino-amide and hydroxy-amide, Compounds with activity in the micromolar range were actually a starting point for the synthesis of new protease inhibitors. (C) Elsevier, Paris.