3-Amino-4-methoxy-9-phenyl-5,8,10-trioxabicyclo[4.4.0]decan-2-ol | 6038-60-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-Amino-4-methoxy-9-phenyl-5,8,10-trioxabicyclo[4.4.0]decan-2-ol
• 英文别名: 7-amino-6-methoxy-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-8-ol
• CAS: 6038-60-4
• 化学式: C₁₄H₁₉NO₅
• 分子量: 281.3
• InChiKey: GQJOKDVZCWTBHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  83.2
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Glucose derivative, and cell imaging method and imaging agent using said derivative
  申请人：HIROSAKI UNIVERSITY

  公开号：US10001487B2

  公开（公告）日：2018-06-19

  Provided is a glucose derivative, which is taken into cells via a membrane sugar transport system and is represented by formula (1). Also provided are an imaging agent and an imaging method for a cell or intracellular molecule using said glucose derivative. Further provided are a method for detecting cancer cells with good accuracy using said glucose derivative and an imaging agent to be used in said method. More specifically provided are D-glucose derivatives and L-glucose derivatives in which glucose is bound to the 7-position of a fluorescent molecular group with a coumarin backbone or a quinolone backbone. Also provided are a cell imaging agent and imaging method using the derivative. A cancer cell imaging agent and imaging method using the L-glucose derivative is also provided. G is a group selected from formulas (G1)-(G4) below.

  本发明提供了一种葡萄糖衍生物，它可通过膜糖转运系统进入细胞，由式（1）表示。还提供了一种成像剂和一种使用所述葡萄糖衍生物对细胞或细胞内分子进行成像的方法。此外，还提供了一种使用所述葡萄糖衍生物精确检测癌细胞的方法和一种用于所述方法的成像剂。更具体地说，提供了 D-葡萄糖衍生物和 L-葡萄糖衍生物，其中葡萄糖与具有香豆素骨架或醌骨架的荧光分子基团的 7 位结合。还提供了一种细胞成像剂和使用该衍生物的成像方法。还提供了一种癌细胞成像剂和使用 L-葡萄糖衍生物的成像方法。G 是选自以下式 (G1)-(G4) 的基团。
• NOVEL GLUCOSE DERIVATIVE, AND CELL IMAGING METHOD AND IMAGING AGENT USING SAID DERIVATIVE
  申请人：HIROSAKI UNIVERSITY

  公开号：US20170122955A1

  公开（公告）日：2017-05-04

  Provided is a glucose derivative, which is taken into cells via a membrane sugar transport system and is represented by formula (1). Also provided are an imaging agent and an imaging method for a cell or intracellular molecule using said glucose derivative. Further provided are a method for detecting cancer cells with good accuracy using said glucose derivative and an imaging agent to be used in said method. More specifically provided are D-glucose derivatives and L-glucose derivatives in which glucose is bound to the 7-position of a fluorescent molecular group with a coumarin backbone or a quinolone backbone. Also provided are a cell imaging agent and imaging method using the derivative. A cancer cell imaging agent and imaging method using the L-glucose derivative is also provided. G is a group selected from formulas (G1)-(G4) below.