7-(4-methoxyphenyl)-1-methyl-3-phenylpyrazolo[3,4-b]pyrrolo[3,4-d]pyridine-6,8(3H,7H)-dione | 1207714-84-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 7-(4-methoxyphenyl)-1-methyl-3-phenylpyrazolo[3,4-b]pyrrolo[3,4-d]pyridine-6,8(3H,7H)-dione
• 英文别名: LASSBio-1424；11-(4-Methoxyphenyl)-3-methyl-5-phenyl-4,5,7,11-tetrazatricyclo[7.3.0.02,6]dodeca-1,3,6,8-tetraene-10,12-dione
• CAS: 1207714-84-8
• 化学式: C₂₂H₁₆N₄O₃
• 分子量: 384.394
• InChiKey: UTCCDANORKVNHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  77.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-氨基-3-甲基-1-苯基吡唑 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 反应 10.0h， 生成 7-(4-methoxyphenyl)-1-methyl-3-phenylpyrazolo[3,4-b]pyrrolo[3,4-d]pyridine-6,8(3H,7H)-dione
  参考文献：
  名称：

  Catalyst-free Synthesis of pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine Derivatives by Aza-Diels-Alder Reaction

  摘要：

  通过以二甲苯为溶剂，利用5-氨基吡唑、DMF-DMA（或TMOF）与N-芳基马来酰亚胺的无催化剂双组分和一锅法反应，合成了一系列吡唑并[3,4-b]吡咯并[3,4-d]吡啶衍生物。该方法相较于其他测试过的方法，在反应条件更温和、操作更简便、反应时间更短及产率良好等方面表现出优势。

  DOI：

  10.2174/1570178611310050006

文献信息

• Microwave-assisted synthesis and structure–activity relationships of neuroactive pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives
  作者：Nailton M. Nascimento-Júnior、Thaiana C.F. Mendes、Daniella M. Leal、Claudia Maria N. Corrêa、Roberto T. Sudo、Gisele Zapata-Sudo、Eliezer J. Barreiro、Carlos A.M. Fraga

  DOI：10.1016/j.bmcl.2009.11.038

  日期：2010.1

  We described herein the optimization of the synthetic methodology exploited to obtain the pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine sedative prototype 1a and novel analogues designed by successive molecular simplifications. By applying microwave irradiation during the hetero Diels-Alder key-step to obtain the heterotricyclic scaffold, under solvent-free conditions, we were able to obtain the desired compounds in drastically shorter times and better yields. Additionally, in vivo evaluation of the sedative effects of these heterocyclic derivatives showed that 1a and the novel structurally-related analogue 1e were the most efficient compounds to impair the locomotor activity in mice at the dose of 10 mu mol/kg. (C) 2009 Elsevier Ltd. All rights reserved.
• Catalyst-free Synthesis of pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine Derivatives by Aza-Diels-Alder Reaction
  作者：Jairo Quiroga、Angela Valencia、Alfredo Perez、Jaime Galvez、Rodrigo Abonia、Braulio Insuasty

  DOI：10.2174/1570178611310050006

  日期：2013.5.1

  A series of pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives was synthesized via catalyst-free bi-component and one-pot reactions of 5-aminopyrazoles, DMF-DMA (or TMOF) and N-arylmaleimides in xylene as solvent. This protocol showed advantages of milder reaction conditions, easier work-up, shorter reaction times and good yields, over other approaches tested.

  通过以二甲苯为溶剂，利用5-氨基吡唑、DMF-DMA（或TMOF）与N-芳基马来酰亚胺的无催化剂双组分和一锅法反应，合成了一系列吡唑并[3,4-b]吡咯并[3,4-d]吡啶衍生物。该方法相较于其他测试过的方法，在反应条件更温和、操作更简便、反应时间更短及产率良好等方面表现出优势。