2-(Methylsulfanyl)-9-pentofuranosyl-9h-purin-6-amine | 4105-39-9

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 2-(Methylsulfanyl)-9-pentofuranosyl-9h-purin-6-amine
• 英文别名: 2-(6-amino-2-methylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
• CAS: 4105-39-9
• 化学式: C₁₁H₁₅N₅O₄S
• 分子量: 313.34
• InChiKey: AJNDEAZTAFKOOO-UHFFFAOYSA-N

物化性质

• 熔点：
  225 °C
• 沸点：
  747.6±70.0 °C(Predicted)
• 密度：
  1.98±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  165
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• Method for identifying purinergic modulators of the olfactory system
  申请人：The University Of Utah

  公开号：EP2410332A1

  公开（公告）日：2012-01-25

  Disclosed are screening methods for detecting compounds that modulate odor sensitivity via purinergic receptors of the olfactory system.

  所公开的是用于检测通过嗅觉系统的嘌呤能受体调节气味敏感性的化合物的筛选方法。
• NON-HYDROLYZABLE NUCLEOSIDE DI- OR TRI-PHOSPHATE DERIVATIVES AND USES THEREOF
  申请人：FISCHER Bilha

  公开号：US20100256086A1

  公开（公告）日：2010-10-07

  The invention provides non-hydrolyzable nucleoside polyphosphate derivatives, e.g., 2MeS-adenosine-β,γ-CH 2 -5′-O-(1-boranotriphosphate), 2MeS-adenosine-β,γ-CCl 2 -5′-O-(1-boranotriphosphate), 2-MeS-adenosine-5′-dichloro methylene-diphosphate, 2-MeS-adenosine-5′-difluoromethylene-diphosphate and 2MeS-adenosine-5′-O-(1-boranodiphosphate), as well as pharmaceutical compositions thereof. These compounds are useful for prevention or treatment of diseases or disorders modulated by P2Y-receptors such as type 2 diabetes, and for pain control.