2-hydroxy-3-[4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl]propyl 2-methylacrylate | 1352619-25-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-hydroxy-3-[4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl]propyl 2-methylacrylate
• 英文别名: HTMA；[2-Hydroxy-3-[4-(hydroxymethyl)triazol-1-yl]propyl] 2-methylprop-2-enoate；[2-hydroxy-3-[4-(hydroxymethyl)triazol-1-yl]propyl] 2-methylprop-2-enoate
• CAS: 1352619-25-0
• 化学式: C₁₀H₁₅N₃O₄
• 分子量: 241.247
• InChiKey: XOGUJSPWBMOTLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  97.5
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  甲基丙烯酸缩水甘油酯 、 2-丙炔-1-醇 在 sodium azide 、 氯化铵 、 copper(I) bromide 作用下， 反应 2.0h， 生成 2-hydroxy-3-[4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl]propyl 2-methylacrylate
  参考文献：
  名称：

  A novel hydrophilic polystyrene-based beads for hydrophilic interaction chromatography by surface-initiated atom transfer radical polymerization

  摘要：

  A one-step procedure to hydrophilize monodisperse poly (chloromethyl-styrene-co-divinylbenzene) beads has been presented with 2-hydroxy-3-[4- (hydroxymethyl)-1H-1,2,3-triazol-l-yl] propyl 2-methylacrylate (HTMA) as monomer by surface-initiated atom transfer radical polymerization (SI-ATRP). The length of the grafted poly (HTMA) chain was varied via controlling the ratio of HTMA to initiator on the surface of the beads. Using these grafted beads as the stationary phase in hydrophilic interaction chromatography, good separation was obtained for nucleosides in the mobile phase of acetonitrile-water. It was also found that the retention time and selectivity of solutes showed a positive relationship with the length of the grafted poly (HTMA) chain. (C) 2010 Yin Mao Wei. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2010.07.036

文献信息

• A novel hydrophilic polystyrene-based beads for hydrophilic interaction chromatography by surface-initiated atom transfer radical polymerization
  作者：Xiao Jun Dai、Yuan He、Yin Mao Wei、Bo Lin Gong

  DOI：10.1016/j.cclet.2010.07.036

  日期：2011.2

  A one-step procedure to hydrophilize monodisperse poly (chloromethyl-styrene-co-divinylbenzene) beads has been presented with 2-hydroxy-3-[4- (hydroxymethyl)-1H-1,2,3-triazol-l-yl] propyl 2-methylacrylate (HTMA) as monomer by surface-initiated atom transfer radical polymerization (SI-ATRP). The length of the grafted poly (HTMA) chain was varied via controlling the ratio of HTMA to initiator on the surface of the beads. Using these grafted beads as the stationary phase in hydrophilic interaction chromatography, good separation was obtained for nucleosides in the mobile phase of acetonitrile-water. It was also found that the retention time and selectivity of solutes showed a positive relationship with the length of the grafted poly (HTMA) chain. (C) 2010 Yin Mao Wei. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.