4-Chloro-2-(2-methoxyethoxy)pyridine | 1346809-08-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Chloro-2-(2-methoxyethoxy)pyridine
• 英文别名: 4-chloro-2-(2-methoxyethoxy)pyridine
• CAS: 1346809-08-2
• 化学式: C₈H₁₀ClNO₂
• 分子量: 187.626
• InChiKey: NKHJOEREYHJMEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  tert-butyl (6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazol-2-yl)carbamate 、 4-Chloro-2-(2-methoxyethoxy)pyridine 在 Pd-118 作用下， 以 水 、 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Discovery of potent, selective small molecule inhibitors of α-subtype of type III phosphatidylinositol-4-kinase (PI4KIIIα)

  摘要：

  The discovery and optimisation of novel, potent and selective small molecule inhibitors of the alpha-isoform of type III phosphatidylinositol-4-kinase (PI4K alpha) are described. Lead compounds show cellular activity consistent with their PI4K alpha potency inhibiting the accumulation of IP1 after PDGF stimulation and reducing cellular PIP, PIP2 and PIP3 levels. Hence, these compounds are useful in vitro tools to delineate the complex biological pathways involved in signalling through PI4Ka. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.05.093

文献信息

• Discovery of potent, selective small molecule inhibitors of α-subtype of type III phosphatidylinositol-4-kinase (PI4KIIIα)
  作者：Piotr Raubo、David M. Andrews、Jennifer C. McKelvie、Graeme R. Robb、James M. Smith、Martin E. Swarbrick、Michael J. Waring

  DOI：10.1016/j.bmcl.2015.05.093

  日期：2015.8

  The discovery and optimisation of novel, potent and selective small molecule inhibitors of the alpha-isoform of type III phosphatidylinositol-4-kinase (PI4K alpha) are described. Lead compounds show cellular activity consistent with their PI4K alpha potency inhibiting the accumulation of IP1 after PDGF stimulation and reducing cellular PIP, PIP2 and PIP3 levels. Hence, these compounds are useful in vitro tools to delineate the complex biological pathways involved in signalling through PI4Ka. (C) 2015 Elsevier Ltd. All rights reserved.