[1-(N-difluoromethyl-1,2-dihydropyrid-2-one-4-carbonyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid | 1254180-99-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: [1-(N-difluoromethyl-1,2-dihydropyrid-2-one-4-carbonyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
• 英文别名: 2-(1-(1-(difluoromethyl)-2-oxo-1,2-dihydropyridine-4-carbonyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid；2-[1-[1-(difluoromethyl)-2-oxopyridine-4-carbonyl]-5-methoxy-2-methylindol-3-yl]acetic acid
• CAS: 1254180-99-8
• 化学式: C₁₉H₁₆F₂N₂O₅
• 分子量: 390.343
• InChiKey: XKMLYOGTLFCDCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  88.8
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  [1-(N-difluoromethyl-1,2-dihydropyrid-2-one-4-carbonyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid benzyl ester 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 、 乙酸乙酯 为溶剂， 25.0 ℃ 、310.27 kPa 条件下， 反应 24.0h， 以75%的产率得到[1-(N-difluoromethyl-1,2-dihydropyrid-2-one-4-carbonyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
  参考文献：
  名称：

  Synthesis and biological evaluation of indomethacin analogs possessing a N-difluoromethyl-1,2-dihydropyrid-2-one ring system: A search for novel cyclooxygenase and lipoxygenase inhibitors

  摘要：

  A novel class of indomethacin analogs were synthesized wherein a N-difluoromethyl-1,2-dihydropyrid-2-one moiety (5-LOX pharmacophore) was attached at its C-4 or C-5 position via either a C=O (14a-b) or CH2 (19a-b) linker to the indole N-1-position. In this regard, replacement of the 4-chlorobenzoyl group present in indomethacin by N-difluoromethyl-1,2-dihydropyrid-2-one-4-(or 5-)carbonyl and N-difluoromethyl-1,2-dihydropyrid-2-one-4-yl(or 5-yl)methylene moieties furnished compounds showing no inhibitory activities against the COX-2/5-LOX enzymes (except for the weak but selective COX-2 inhibitor 19a, COX-2 IC50 = 31 mu M), and moderate in vivo anti-inflammatory activities (except for the methylene compound 19a that was inactive). These structure-activity data indicate replacement of the 4-chlorobenzoyl group present in indomethacin by a N-difluoromethyl-1,2-dihydropyrid-2-one ring system connected by a C=O or CH2 linker is not a suitable approach for the design of dual COX-2/5-LOX inhibitory analogs of indomethacin. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.07.132

文献信息

• Synthesis and biological evaluation of indomethacin analogs possessing a N-difluoromethyl-1,2-dihydropyrid-2-one ring system: A search for novel cyclooxygenase and lipoxygenase inhibitors
  作者：Morshed A. Chowdhury、Zhangjian Huang、Khaled R.A. Abdellatif、Ying Dong、Gang Yu、Carlos A. Velázquez、Edward E. Knaus

  DOI：10.1016/j.bmcl.2010.07.132

  日期：2010.10

  A novel class of indomethacin analogs were synthesized wherein a N-difluoromethyl-1,2-dihydropyrid-2-one moiety (5-LOX pharmacophore) was attached at its C-4 or C-5 position via either a C=O (14a-b) or CH2 (19a-b) linker to the indole N-1-position. In this regard, replacement of the 4-chlorobenzoyl group present in indomethacin by N-difluoromethyl-1,2-dihydropyrid-2-one-4-(or 5-)carbonyl and N-difluoromethyl-1,2-dihydropyrid-2-one-4-yl(or 5-yl)methylene moieties furnished compounds showing no inhibitory activities against the COX-2/5-LOX enzymes (except for the weak but selective COX-2 inhibitor 19a, COX-2 IC50 = 31 mu M), and moderate in vivo anti-inflammatory activities (except for the methylene compound 19a that was inactive). These structure-activity data indicate replacement of the 4-chlorobenzoyl group present in indomethacin by a N-difluoromethyl-1,2-dihydropyrid-2-one ring system connected by a C=O or CH2 linker is not a suitable approach for the design of dual COX-2/5-LOX inhibitory analogs of indomethacin. (C) 2010 Elsevier Ltd. All rights reserved.