3-(2-(1H-indol-3-yl)ethyl)-2-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)thiazolidin-4-one | 1334241-95-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(2-(1H-indol-3-yl)ethyl)-2-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)thiazolidin-4-one
• 英文别名: 3-[2-(1H-indol-3-yl)ethyl]-2-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-1,3-thiazolidin-4-one
• CAS: 1334241-95-0
• 化学式: C₂₇H₂₈N₄O₂S
• 分子量: 472.611
• InChiKey: XDYDHQACAANGGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  86.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-[N-甲基-N-(2-吡啶基)氨基]乙醇 在 sodium hydride 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 0.84h， 生成 3-(2-(1H-indol-3-yl)ethyl)-2-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)thiazolidin-4-one
  参考文献：
  名称：

  Thiazolidin-4-one and thiazinan-4-one derivatives analogous to rosiglitazone as potential antihyperglycemic and antidyslipidemic agents

  摘要：

  A number of thiazolidin-4-one and thiazinan-4-one derivatives were prepared by three component condensation in one pot reaction method. These compounds were evaluated for anti-hyperglycemic activity by in vitro and in vivo assay systems. The compounds with thiazolidin-4-one and thiazinan-4-one moieties exhibited significant anti-hyperglycemic activity. A few compounds (3a, 3b, 4a and 4b) have exhibited both anti-hyperglycemic and anti-dyslipidemic activities. Among them the thiazinan-4-one derivative 4a showed maximal (45%) improvement in oral glucose tolerance test in db/db mice at 30 mg/kg oral dose. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.01.054

文献信息

• Thiazolidin-4-one and thiazinan-4-one derivatives analogous to rosiglitazone as potential antihyperglycemic and antidyslipidemic agents
  作者：Saman Raza、Swayam P. Srivastava、Daya S. Srivastava、Arvind K. Srivastava、W. Haq、S.B. Katti

  DOI：10.1016/j.ejmech.2013.01.054

  日期：2013.5

  A number of thiazolidin-4-one and thiazinan-4-one derivatives were prepared by three component condensation in one pot reaction method. These compounds were evaluated for anti-hyperglycemic activity by in vitro and in vivo assay systems. The compounds with thiazolidin-4-one and thiazinan-4-one moieties exhibited significant anti-hyperglycemic activity. A few compounds (3a, 3b, 4a and 4b) have exhibited both anti-hyperglycemic and anti-dyslipidemic activities. Among them the thiazinan-4-one derivative 4a showed maximal (45%) improvement in oral glucose tolerance test in db/db mice at 30 mg/kg oral dose. (C) 2013 Elsevier Masson SAS. All rights reserved.