2-[2-fluoro-4-chloro-5-isopropoxyphenyl]-4-methyl-5-trifluoromethyl-pyridazin-3-one | 188489-04-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-[2-fluoro-4-chloro-5-isopropoxyphenyl]-4-methyl-5-trifluoromethyl-pyridazin-3-one
• 英文别名: 2-(4-chloro-2-fluoro-5-isopropoxyphenyl)-4-methyl-5-trifluoromethylpyridazin-3-one；2-(2-Fluoro-4-chloro-5-isopropoxyphenyl)-4-methyl-5-trifluoromethylpyridazin-3-one；2-(4-chloro-2-fluoro-5-propan-2-yloxyphenyl)-4-methyl-5-(trifluoromethyl)pyridazin-3-one
• CAS: 188489-04-5
• 化学式: C₁₅H₁₃ClF₄N₂O₂
• 分子量: 364.727
• InChiKey: WCEVCASYBVMSFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  41.9
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-[2-fluoro-4-chloro-5-isopropoxyphenyl]-4-methyl-5-trifluoromethyl-pyridazin-3-one 在 硫酸 作用下， 反应 0.17h， 生成 2-(4-chloro-2-fluoro-5-hydroxyphenyl)-4-methyl-5-trifluoromethyl-3-oxo-2,3-dihydropyridazine
  参考文献：
  名称：

  Pyridazin-3-one derivatives, their use, and intermediates for their production

  摘要：

  提供具有以下结构式的新型肼酮[2]，其中R3为氢、烷基、卤代烷基或烷氧基烷基；Q为[Q-1]、[Q-2]、[Q-3]、[Q-4]或[Q-5]，用于形成除草剂的活性成分的中间体。

  公开号：

  US06348628B1
• 作为产物：
  描述：

  3,3,3-trifluoro-2-oxo-propanal 1-(4-chloro-2-fluoro-5-isopropoxyphenylhydrazone) 、 乙氧甲酰基亚乙基三苯基 以 四氢呋喃 为溶剂， 生成 2-[2-fluoro-4-chloro-5-isopropoxyphenyl]-4-methyl-5-trifluoromethyl-pyridazin-3-one
  参考文献：
  名称：

  Pyridazin-3-one derivatives, their use, and intermediates for their

  摘要：

  提供了式[1]的新型吡啶并嗪-3-酮衍生物，其作为除草剂的活性成分，其中R.sup.1是卤代烷基；R.sup.2和R.sup.3相同或不同，可以是氢、烷基、卤代烷基或烷氧基烷基；Q是[Q-1]、[Q-2]、[Q-3]、[Q-4]或[Q-5]。还提供了它们的用途和生产中间体。

  公开号：

  US06090753A1
• 作为试剂：
  描述：

  2-(4-chloro-2-fluoro-5-isopropoxyphenyl)-4-cyano-5-trifluoromethylpyridazin-3-one 、 、 乙醚 、 甲基碘化镁 、 盐酸 在 氮气 、 乙酸乙酯 、 碳酸氢钠 、 2-[2-fluoro-4-chloro-5-isopropoxyphenyl]-4-methyl-5-trifluoromethyl-pyridazin-3-one 作用下， 以 四氢呋喃 为溶剂， 反应 0.33h， 以to afford 0.467 g of 2-(4-chloro-2-fluoro-5-isopropoxyphenyl)-4-methyl-5-trifluoromethylpyridazin-3-one (compound 2-5)的产率得到2-[2-fluoro-4-chloro-5-isopropoxyphenyl]-4-methyl-5-trifluoromethyl-pyridazin-3-one
  参考文献：
  名称：

  Substituted pyridazin-3-one compounds

  摘要：

  4-甲基吡嗪-3-酮化合物的化学式为：##STR1## [其中，X代表氢原子或氟原子，Y代表氢原子，C.sub.1-C.sub.6烷氧基，C.sub.3-C.sub.6烷氧基或C.sub.3-C.sub.6烷氧基]，通过与甲基化试剂反应制备4-氰基吡嗪-3-酮化合物的化学式为：##STR2## 因此，上述4-氰基吡嗪-3-酮化合物可用于作为中间体制备上述除草剂性的4-甲基吡嗪-3-酮化合物。

  公开号：

  US06093818A1

文献信息

• Herbicidal composition
  申请人：Sumitomo Chemical Company, Limited

  公开号：US06147030A1

  公开（公告）日：2000-11-14

  A herbicidal composition for foliar treatment is described, which contains as active ingredients, (a) a compound of general formula [1] wherein R is alkyl, cycloalkyl, alkenyl, dimethylamino, or diethylamino; and (b) a compound selected from the group consisting of imazethapyr or a salt thereof, imazaquin or a salt thereof, imazamox or a salt thereof, acifluorfen-sodium, lactofen, fomesafen, clethodim, sethoxydim, fenoxaprop-P-ethyl, fluazifop-P-butyl, and quizalofop-P-ethyl. The herbicidal composition is useful for effective control of a wide variety of weeds in upland fields, particularly in soybean fields. Also described are a weeding method by foliar treatment of weeds with the above herbicidal composition; and use as a herbicide for foliar treatment, of a mixture of the above active ingredients. ##STR1##

  本发明涉及一种叶面处理用除草剂组合物，其包含以下活性成分：(a) 一种通式[1]中R为烷基、环烷基、烯基、二甲基氨基或二乙基氨基的化合物；以及(b) 从以下组中选择的化合物：咪唑草胺或其盐、伊马津赛或其盐、伊马唑喹或其盐、乙酰氟苯酸钠、乳沃苯、福美双、克莱索地、塞托草胺、草灭脲-乙酯、氟草酸丁酯和草丹磷乙酯。该除草剂组合物对于有效控制干地上各种杂草，特别是大豆田非常有用。本发明还涉及一种通过叶面处理使用上述除草剂组合物的除草方法；以及将上述活性成分混合物用作叶面处理用除草剂。##STR1##
• Herbicide compositions
  申请人：Sumitomo Chemical Company, Limited

  公开号：US06197727B1

  公开（公告）日：2001-03-06

  The present invention provides herbicide compositions for foliar treatment each containing as active ingredients, a 2-chloro-4-fluoro-5-(4methyl-5-trifluoromethyl-3-pyridazinon-2-chloro-2-yl)phenyl C1-C5 non-cyclic hydrocarbyl ether and one selected from the group consisting of (RS)-2-(4-chloro-2methylphenoxy)propionic acid, 2,4-dichlorophenoxyacetic acid, (4-chloro-2-methyl)phenoxyacetic acid, 2-[[[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)-amino]carbonyl]amino]sulfonyl] benzoate, 2-chloro-N-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]benzenesulfonamide, ethyl (R)-2-[4(6-chloro-1 3-benzoxazol-2-yloxy)phenoxy]propanoate, methyl (RS)-2-[4-(2,4-dichlorophenoxy)phenoxy]propionate, 3,5-dibromo-4-hydroxybenzonitrile, 4-hydroxy-3,5-diiodobenzonitrile, 3-(4-isopropylphenyl)-N′, N′-dimethylurea, N′-(3-chloro-4-methylphenyl)-N,N-dimethylurea and N-(2,4-difluorophenyl)-2-[3-(trifluoromethyl)phenoxy]-3-pyridinecarboxamide; and a weeding method by foliar treatment of weeds therewith. The present compositions can be used for effective control of various weeds occurring on crop lands or non-crop lands, in which case the herbicidal activity is synergistically enhanced as compared with the cases where the active ingredients are used separately, which makes possible low-dose application, and the herbicidal spectra are expanded, so that a wide variety of weeds can be selectively controlled, particularly on wheat, barley, oat, or rye fields.

  本发明提供了一种除草剂组合物，用于叶面处理，每种组合物均含有以下活性成分：2-氯-4-氟-5-(4-甲基-5-三氟甲基-3-吡啶酮-2-氯-2-基)苯基C1-C5非环烃基醚和从以下组合中选择的一种：(RS)-2-(4-氯-2-甲基苯氧基)丙酸、2,4-二氯苯氧乙酸、(4-氯-2-甲基)苯氧乙酸、2-[[[(4-甲氧基-6-甲基-1,3,5-三嗪-2-基)氨基]羰基]氨基]磺酰]苯甲酸酯、2-氯-N-[[[(4-甲氧基-6-甲基-1,3,5-三嗪-2-基)氨基]羰基]苯磺酰]胺、乙基(R)-2-[[4-(6-氯-1,3-苯并噁唑-2-氧基)苯氧基]丙酸酯、甲基(RS)-2-[[4-(2,4-二氯苯氧基)苯氧基]丙酸甲酯、3,5-二溴-4-羟基苯甲腈、4-羟基-3,5-二碘苯甲腈、3-(4-异丙基苯基)-N'，N'-二甲基脲、N'-(3-氯-4-甲基苯基)-N，N-二甲基脲和N-(2,4-二氟苯基)-2-[[3-(三氟甲基)苯氧基]吡啶-3-羧酰胺；以及通过叶面处理除草草本植物的方法。本发明的组合物可用于有效控制作物土地或非作物土地上出现的各种杂草，与单独使用活性成分的情况相比，该除草剂活性具有协同增强作用，从而可以进行低剂量应用，并且除草谱扩展，从而可以选择性地控制各种杂草，特别是在小麦、大麦、燕麦或黑麦田上。
• Production of pyridazine herbicides
  申请人：Sumitomo Chemical Company, Limited

  公开号：US06333413B1

  公开（公告）日：2001-12-25

  Carboxylic acids of formula (1): wherein R2 and R3 are independently hydrogen or C1-C3 alkyl, and Q is optionally substituted phenyl, can be easily converted by ring closing into pyridazin-3-one derivatives of formula (7): The carboxylic acids of formula (1) can be produced by reacting hydrazone compounds of formula (5): wherein R3 and Q are as defined above, with malonic acid derivatives of formula (6): R2CH(COOH)2 wherein R2 is as defined above, in the presence of a base.

  公式（1）的羧酸：其中R2和R3独立地为氢或C1-C3烷基，Q是可选取代的苯基，可以通过环闭合轻松转化为公式（7）的吡嗪-3-酮衍生物：公式（1）的羧酸可以通过以下反应生成：公式（5）的腙化合物与公式（6）的丙二酸衍生物反应，在碱的存在下，其中R3和Q如上所定义，R2如上所定义。
• Substituted Pyridazin-3-one compounds
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP0943610A1

  公开（公告）日：1999-09-22

  4-Methylpyridazin-3-one compounds of the formula : [wherein, X represents a hydrogen or fluorine atom, and Y represents a hydrogen atom, a C1-C6 alkoxy, C3-C6 alkenyloxy or C3-C6 alkynyloxy group] are produced by reacting 4-cyanopyridazin-3-one compounds of the formula : with a methylating agent. Therefore, the above 4-cyanopyridazin-3-one compounds are useful as intermediates for producing the above herbicidal 4-methylpyridazin-3-one compounds.

  式中的 4-甲基哒嗪-3-酮化合物： [式中，X 代表氢原子或氟原子，Y 代表氢原子、C1-C6 烷氧基、C3-C6 烯氧基或 C3-C6 烷炔氧基]的 4-氰基哒嗪-3-酮化合物与甲基化剂反应制得： 的 4-氰基哒嗪-3-酮化合物与甲基化剂反应而制得。因此，上述 4-氰基哒嗪-3-酮化合物可作为生产上述除草剂 4-甲基哒嗪-3-酮化合物的中间体。
• HERBICIDE COMPOSITIONS
  申请人：SUMITOMO CHEMICAL COMPANY LIMITED

  公开号：EP0968650A1

  公开（公告）日：2000-01-05

  The present invention provides herbicide compositions for foliar treatment each containing as active ingredients, a 2-chloro-4-fluoro-5-(4-methyl-5-trifluoromethyl-3-pyridazinon-2-yl)phenyl C1-C5 non-cyclic hydrocarbyl ether and one selected from the group consisting of (RS)-2-(4-chloro-2-methylphenoxy)propionic acid, 2,4-dichlorophenoxyacetic acid, (4-chloro-2-methyl)phenoxyacetic acid, 2-[[[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)-amino]carbonyl]amino]sulfonyl] benzoate, 2-chloro-N-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]benzenesulfonamide, ethyl (R)-2-[4-(6-chloro-1,3-benzoxazol-2-yloxy)phenoxy]propanoate, methyl (RS)-2-[4-(2,4-dichlorophenoxy)phenoxy]propionate, 3,5-dibromo-4-hydroxybenzonitrile, 4-hydroxy-3,5-diiodobenzonitrile, 3-(4-isopropylphenyl)-N',N'-dimethylurea, N'-(3-chloro-4-methylphenyl)-N,N-dimethylurea and N-(2,4-difluorophenyl)-2-[3-(trifluoromethyl)phenoxy]-3-pyridinecarboxamide; and a weeding method by foliar treatment of weeds therewith. The present compositions can be used for effective control of various weeds occurring on crop lands or non-crop lands, in which case the herbicidal activity is synergistically enhanced as compared with the cases where the active ingredients are used separately, which makes possible low-dose application, and the herbicidal spectra are expanded, so that a wide variety of weeds can be selectively controlled, particularly on wheat, barley, oat, or rye fields.

  本发明提供了用于叶面处理的除草剂组合物，每种组合物都含有作为活性成分的2-氯-4-氟-5-(4-甲基-5-三氟甲基-3-哒嗪酮-2-基)苯基C1-C5非环烃基醚和选自由(RS)-2-(4-氯-2-甲基苯氧基)丙酸组成的组中的一种、2,4-二氯苯氧乙酸、(4-氯-2-甲基)苯氧乙酸、2-[[[[(4-甲氧基-6-甲基-1,3,5-三嗪-2-基)-氨基]羰基]氨基]磺酰基]苯甲酸、2-氯-N-[[(4-甲氧基-6-甲基-1,3,5-三嗪-2-基)氨基]羰基]氨基]苯磺酰胺，(R)-2-[4-(6-氯-1,3-苯并恶唑-2-基氧基)苯氧基]丙酸乙酯，(RS)-2-[4-(2,4-二氯苯氧基)苯氧基]丙酸甲酯，3、5-二溴-4-羟基苯腈、4-羟基-3,5-二碘苯腈、3-(4-异丙基苯基)-N',N'-二甲基脲、N'-(3-氯-4-甲基苯基)-N,N-二甲基脲和 N-(2,4-二氟苯基)-2-[3-(三氟甲基)苯氧基]-3-吡啶甲酰胺；以及用其对杂草进行叶面处理的除草方法。 本发明的组合物可用于有效控制作物地或非作物地中出现的各种杂草，在这种情况下，与单独使用活性成分的情况相比，除草活性得到了协同增强，这使得低剂量施用成为可能，并且除草光谱得到了扩展，从而可以选择性地控制多种杂草，特别是小麦、大麦、燕麦或黑麦田中的杂草。