3-(3-phenyl-1,2,4-oxadiazol-5-yl)propanol | 172678-75-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(3-phenyl-1,2,4-oxadiazol-5-yl)propanol
• 英文别名: 3-(3-phenyl-1,2,4-oxadiazol-5-yl)propan-1-ol
• CAS: 172678-75-0
• 化学式: C₁₁H₁₂N₂O₂
• 分子量: 204.228
• InChiKey: CIXUYXVINYQKCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  59.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-(3-苯基-1,2,4-噁二唑)丙酸盐 以 四氢呋喃 、 甲醇 为溶剂， 生成 3-(3-phenyl-1,2,4-oxadiazol-5-yl)propanol
  参考文献：
  名称：

  Erythromycin derivatives

  摘要：

  从以下化合物中选择的一种化合物，其中R.sub.1和R.sub.2分别从氢和由最多24个碳原子组成的可选地由至少一个来自氧、硫和氮的杂原子中选取的可选地不饱和碳氢化合物组成的群中选择，并且可选地具有至少一个官能团或者一起形成##STR2##，R'.sub.1和R'.sub.2分别从氢和由最多23个碳原子组成的可选地由至少一个来自氮、氧和硫的杂原子中选取的可选地不饱和碳氢化合物组成的群中选择，并且可选地具有至少一个官能团，Z为1至18个碳原子的有机羧酸的酰基或氢，波浪线表示10-甲基可能具有R或S构型或R+S混合物及其无毒的、药学上可接受的酸加盐，具有抗生素性能。

  公开号：

  US05656607A1

文献信息

• Propanal derivatives
  申请人：Roussel Uclaf

  公开号：US05760233A1

  公开（公告）日：1998-06-02

  A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and an optionally unsaturated hydrocarbon of up to 24 carbon atoms optionally interrupted by at least one heteroatom selected from the group consisting of oxygen, sulfur and nitrogen and optionally having at least one functional group or taken together form ##STR2## and R'.sub.1 and R'.sub.2 are individually selected from the group consisting of hydrogen and an optionally unsaturated hydrocarbon of up to 23 carbon atoms optionally interrupted by at least one heteroatom selected from the group consisting of nitrogen, oxygen and sulfur and optionally having at least one functional group, Z is hydrogen or acyl of an organic carboxylic acid of 1 to 18 carbon atoms and the wavy line indicates the 10-methyl may have R or S configuration or a mixture of R+S and their non-toxic, pharmaceutically acceptable acid addition salts having antibiotic properties.

  从以下化合物组合中选择的化合物，其中化合物的结构式为##STR1##其中R.sub.1和R.sub.2分别选择自氢和具有最多24个碳原子的可选非饱和碳氢化合物，可选地由至少一个来自氧、硫和氮的杂原子中断，并且可选地具有至少一个官能团或共同形成##STR2##，R'.sub.1和R'.sub.2分别选择自氢和具有最多23个碳原子的可选非饱和碳氢化合物，可选地由至少一个来自氮、氧和硫的杂原子中断，并且可选地具有至少一个官能团，Z为有机羧酸的酰基，其具有1至18个碳原子，波浪线表示10-甲基可以具有R或S构型或R+S混合物，以及其无毒、药学上可接受的酸盐，具有抗生素特性。
• US5656607A
  申请人：——

  公开号：US5656607A

  公开（公告）日：1997-08-12
• US5760233A
  申请人：——

  公开号：US5760233A

  公开（公告）日：1998-06-02
• Erythromycin derivatives
  申请人：Roussel Uclaf

  公开号：US05656607A1

  公开（公告）日：1997-08-12

  A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and an optionally unsaturated hydrocarbon of up to 24 carbon atoms optionally interrupted by at least one heteroatom selected from the group consisting of oxygen, sulfur and nitrogen and optionally having at least one functional group or taken together form ##STR2## and R'.sub.1 and R'.sub.2 are individually selected from the group consisting of hydrogen and an optionally unsaturated hydrocarbon of up to 23 carbon atoms optionally interrupted by at least one heteroatom selected from the group consisting of nitrogen, oxygen and sulfur and optionally having at least one functional group, Z is hydrogen or acyl of an organic carboxylic acid of 1 to 18 carbon atoms and the wavy line indicates the 10-methyl may have R or S configuration or a mixture of R+S and their non-toxic, pharmaceutically acceptable acid addition salts having antibiotic properties.

  从以下化合物中选择的一种化合物，其中R.sub.1和R.sub.2分别从氢和由最多24个碳原子组成的可选地由至少一个来自氧、硫和氮的杂原子中选取的可选地不饱和碳氢化合物组成的群中选择，并且可选地具有至少一个官能团或者一起形成##STR2##，R'.sub.1和R'.sub.2分别从氢和由最多23个碳原子组成的可选地由至少一个来自氮、氧和硫的杂原子中选取的可选地不饱和碳氢化合物组成的群中选择，并且可选地具有至少一个官能团，Z为1至18个碳原子的有机羧酸的酰基或氢，波浪线表示10-甲基可能具有R或S构型或R+S混合物及其无毒的、药学上可接受的酸加盐，具有抗生素性能。