N-[(2R,3R,4S,5R)-3,4,5-三羟基-1-氧代己烷-2-基]乙酰胺 | 35233-39-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: N-[(2R,3R,4S,5R)-3,4,5-三羟基-1-氧代己烷-2-基]乙酰胺
• 英文名称: 2-Acetamido-2,6-dideoxygalactose
• 英文别名: N-[(2R,3R,4S,5R)-3,4,5-trihydroxy-1-oxohexan-2-yl]acetamide
• CAS: 35233-39-7
• 化学式: C₈H₁₅NO₅
• 分子量: 205.21
• InChiKey: CZRYIXLKTDHMMY-YDKYIBAVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS<br/>[FR] COMPOSÉS ET MÉTHODES POUR LE TRAITEMENT D'INFECTIONS BACTÉRIENNES
  申请人：CIDARA THERAPEUTICS INC

  公开号：WO2018006063A1

  公开（公告）日：2018-01-04

  Compositions and methods for the treatment of bacterial infections include compounds containing dimers of cyclic heptapeptides conjugated to one or more monosaccharide or oligosaccharide moieties. In particular, compounds can be used in the treatment of bacterial infections caused by Gram-negative bacteria.

  用于治疗细菌感染的组合物和方法包括含有环七肽二聚体与一个或多个单糖或寡糖基团结合的化合物。特别是，这些化合物可用于治疗由革兰氏阴性细菌引起的细菌感染。
• [EN] SYNTHETIC OLIGOSACCHARIDES FOR STAPHYLOCOCCUS VACCINE<br/>[FR] OLIGOSACCHARIDES SYNTHÉTIQUES DESTINÉS À UN VACCIN CONTRE UN STAPHYLOCOQUE
  申请人：ANCORA PHARMACEUTICALS INC

  公开号：WO2012145626A1

  公开（公告）日：2012-10-26

  The present invention synthetic oligo-β-(1→6)-glucosamine structures and a methodology which essentially allows for the synthesis of any oligo-β-(1→6)-glucosamine species having a definite number of monosaccharide units, including a set pattern of acetylated and non- acetylated residues. The invention further provides antibodies to these synthetic oligo-β-(1→6)-glucosamines as well as compositions thereof and methods for treating and preventing infections caused by bacteria expressing poly-β-(1→6)-glucosamines, such as Staphylococcus aureus.

  本发明提供了合成寡聚β-(1→6)-葡聚糖结构以及一种方法，基本上允许合成具有明确单糖单位数量的任何寡聚β-(1→6)-葡聚糖物种，包括一组乙酰化和非乙酰化残基的设定模式。该发明还提供了针对这些合成寡聚β-(1→6)-葡聚糖的抗体，以及其组合物和用于治疗和预防由表达多聚β-(1→6)-葡聚糖的细菌引起的感染的方法，例如金黄色葡萄球菌。
• Acid heteropolysaccharide, sulfated polysaccharide and process for producing the same
  申请人：TEIKOKU SEIYAKU KABUSHIKI KAISHA

  公开号：EP0496351A2

  公开（公告）日：1992-07-29

  An acid heteropolysaccharide P-318 which comprises galactose, galacturonic acid, N-acetylfucosamine and pyruvic acid in a ratio of about 2:3:1:1, a sulfated heteropolysaccharide P-318 having a 10 % or less sulfur content which is prepared by sulfating said acid heteropolysaccharide and a process for preparing an acid heteropolysaccharide P-318 which comprises culturing Pseudomonas sp. 318 to produce the acid heteropolysaccharide P-318 and collecting the thus produced acid heteropolysaccharide P-318. The sulfated polysaccharide P-318 of the invention shows a strong antiviral activity in spite of a lower content of sulfate.

  一种酸性杂多糖 P-318，它由半乳糖、半乳糖醛酸、N-乙酰岩藻糖胺和丙酮酸组成，其比例约为 2:3:1:1；一种硫酸化杂多糖 P-318，它的硫含量不超过 10%，是通过硫酸化所述酸性杂多糖制备的；一种制备酸性杂多糖 P-318 的工艺，它包括培养假单胞菌 318 以产生酸性杂多糖 P-318，并收集由此产生的酸性杂多糖 P-318。318 来产生酸性杂多糖 P-318，并收集由此产生的酸性杂多糖 P-318。本发明的硫酸化多糖 P-318 尽管硫酸盐含量较低，但却具有很强的抗病毒活性。
• Human binding molecules having killing activity against staphylococci and uses thereof
  申请人：Crucell Holland B.V.

  公开号：EP2395018A1

  公开（公告）日：2011-12-14

  The present invention provides human binding molecules specifically binding to staphylococci and having killing activity against staphylococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from Staphylococcus.

  本发明提供了与葡萄球菌特异性结合并对葡萄球菌具有杀灭活性的人类结合分子、编码人类结合分子的核酸分子、包含人类结合分子的组合物以及鉴定或生产人类结合分子的方法。人类结合分子可用于诊断、预防和/或治疗由葡萄球菌引起的疾病。
• METHOD AND DEVICE FOR PRODUCING SACCHARIDES AND SACCHARIDE ARRAYS
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP3670521A1

  公开（公告）日：2020-06-24

  The present invention relates to a method and a device for producing saccharides and saccharide arrays. Said method is particularly useful for the synthesis of saccharides in parallel and of high-density saccharide arrays, such as microarrays, which are required for high-throughput screenings.

  本发明涉及一种生产糖和糖阵列的方法和装置。该方法特别适用于平行合成糖类和高密度糖类阵列，如高通量筛选所需的微阵列。