2-ethoxy-2-oxoethyl aminoacetate | 133211-35-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: 2-ethoxy-2-oxoethyl aminoacetate
• 英文别名: Glycyl-glykolsaeure-aethylester；(2-Ethoxy-2-oxoethyl) 2-aminoacetate
• CAS: 133211-35-5
• 化学式: C₆H₁₁NO₄
• 分子量: 161.158
• InChiKey: MEZPPHGRXIQDGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  78.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-ethoxy-2-oxoethyl aminoacetate 在 4-二甲氨基吡啶 、 四丁基碘化铵 、 potassium carbonate 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 生成 2-ethoxy-2-oxoethyl 2-{2-[3-(butylamino)-4-phenoxy-5-sulfamoylbenzoyloxy]acetamido}acetate
  参考文献：
  名称：

  [EN] DRUGS TO TREAT OCULAR DISORDERS
  [FR] MÉDICAMENTS POUR TRAITER DES TROUBLES OCULAIRES

  摘要：

  本发明提供了治疗活性环利尿剂的新前药，包括寡聚前药，以及用于治疗医学疾病的组合物，例如眼部疾病，如青光眼，与眼内压增高相关的疾病或异常，需要神经保护的疾病，年龄相关性黄斑变性或糖尿病视网膜病变。

  公开号：

  WO2019210215A1
• 作为产物：
  描述：

  ethoxycarbonylmethyl N-(tert-butoxycarbonyl)glycinate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 2-ethoxy-2-oxoethyl aminoacetate
  参考文献：
  名称：

  [EN] DRUGS TO TREAT OCULAR DISORDERS
  [FR] MÉDICAMENTS POUR TRAITER DES TROUBLES OCULAIRES

  摘要：

  本发明提供了治疗活性环利尿剂的新前药，包括寡聚前药，以及用于治疗医学疾病的组合物，例如眼部疾病，如青光眼，与眼内压增高相关的疾病或异常，需要神经保护的疾病，年龄相关性黄斑变性或糖尿病视网膜病变。

  公开号：

  WO2019210215A1

文献信息

• Gibian,H.; Luebke,K., Justus Liebigs Annalen der Chemie, 1961, vol. 644, p. 130 - 141
  作者：Gibian,H.、Luebke,K.

  DOI：——

  日期：——
• COMPOSITION COMPRISING A DICARBONYL COMPOUND AND AN AMINO SILICONE, AND PROCESS FOR STRAIGHTENING THE HAIR USING THIS COMPOSITION
  申请人：L'OREAL

  公开号：EP2916802A1

  公开（公告）日：2015-09-16
• COMPOSITION COMPRISING A DICARBONYL COMPOUND AND PROCESS FOR STRAIGHTENING THE HAIR USING THIS COMPOSITION
  申请人：L'OREAL

  公开号：US20150306012A1

  公开（公告）日：2015-10-29

  The present invention relates to a cosmetic composition comprising at least one cationic polymer and/or one amphoteric polymer and at least 3% of one or more dicarbonyl compounds corresponding to formula (I) below and/or hydrates thereof and/or salts thereof, in which formula (I), R=H, COOH, linear or branched C 1 -C 6 alkyl optionally substituted with an OH or COOH or Br radical; phenyl or benzyl optionally substituted with an OH or COOH radical; or alternatively an indolyl radical or formula (A). The invention also relates to a process for straightening keratin fibres, especially the hair, which comprises the application to the hair of the composition of the invention, followed by a straightening step using a straightening iron at a temperature of at least 150° C., preferably ranging from 150 to 250° C.
• DRUGS TO TREAT OCULAR DISORDERS
  申请人：Graybug Vision, Inc.

  公开号：US20210040111A1

  公开（公告）日：2021-02-11

  The present invention provides new prodrugs of therapeutically active loop diuretics, including oligomeric prodrugs, and compositions to treat medical disorders, for example, ocular disorders such as glaucoma, a disorder or abnormality related to an increase in intraocular pressure (IOP), a disorder requiring neuroprotection, age-related macular degeneration, or diabetic retinopathy.
• [EN] COMPOSITION COMPRISING A DICARBONYL COMPOUND AND AN AMINO SILICONE, AND PROCESS FOR STRAIGHTENING THE HAIR USING THIS COMPOSITION<br/>[FR] COMPOSITION COMPRENANT UN COMPOSÉ DICARBONYLE ET UN AMINO-SILICONE, ET PROCÉDÉ DE DÉFRISAGE DES CHEVEUX AU MOYEN DE CETTE COMPOSITION
  申请人：OREAL

  公开号：WO2014072478A1

  公开（公告）日：2014-05-15

  The present invention relates to a cosmetic composition, in particular a hair composition, comprising i) one or more dicarbonyl compounds corresponding to formula (I) below, and/or derivatives thereof and/or hydrates thereof and/or salts thereof: in which formula (I): R represents an atom or group chosen from i) hydrogen, ii) carboxyl –C(O)OH, iii) linear or branched C1-C6 alkyl which is optionally substituted, preferably with at least one hydroxyl -OH radical, carboxyl –C(O)-OH radical or halogen such as Br, iv) optionally substituted phenyl, v) optionally substituted benzyl, iv) and v) preferably being optionally substituted with at least one –OH or –C(O)OH radical, vi) an indolyl radical and vii) an imidazolylmethyl radical and tautomers thereof such as with * representing the part linked to the rest of the molecule, and ii) at least one amino silicone, the composition having a pH of less than or equal to 4, and also to a process for straightening the hair using this composition.