Octopyranose | 6330-68-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Octopyranose
• 英文别名: 6-(1,2,3-trihydroxypropyl)oxane-2,3,4,5-tetrol
• CAS: 6330-68-3；5329-49-7
• 化学式: C₈H₁₆O₈
• 分子量: 240.21
• InChiKey: BIYJBQHXBNFTFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  151
• 氢给体数：
  7
• 氢受体数：
  8

文献信息

• [EN] ARYL NAPHTHALIDE LIGNANS AS ANTI-HIV AGENTS<br/>[FR] LIGNANES DE NAPHTALIDE D'ARYLE EN TANT QU'AGENTS ANTI-VIH
  申请人：UNIV ILLINOIS

  公开号：WO2013019662A1

  公开（公告）日：2013-02-07

  Provided herein are glycosidic aryl naphthalide lignans compounds, such as justiprocumin A isolated from the plant Justicia gendarussa Burm.f. (Acanthaceae), which are effective in the treatment of AIDS and HIV infections.

  本文提供了一种叫做justiprocumin A的糖苷基芳基萘木脂素化合物，它们是从龙胆草（Justicia gendarussa Burm.f.，爵床科）中分离出来的，对治疗艾滋病和HIV感染有效。
• Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith
  申请人：Pulaski P. Steven

  公开号：US20050014729A1

  公开（公告）日：2005-01-20

  A method for preventing or treating dermatological disorders and dermatological disorder-related complications in a subject involves a monotherapy with a Cox-2 inhibitor or a combination therapy with a Cox-2 inhibitor and a dermatological treatment agent. Also described are therapeutic compositions comprising a Cox-2 inhibitor and a dermatological treatment agent. Pharmaceutical compositions and kits for implementing the present method are also described.

  一种预防或治疗受试者的皮肤病和与皮肤病相关并发症的方法涉及使用Cox-2抑制剂进行单独治疗或与Cox-2抑制剂和皮肤治疗剂的联合治疗。还描述了包含Cox-2抑制剂和皮肤治疗剂的治疗组合物。还描述了用于实施本方法的药物组合物和工具包。
• [EN] METHODS, COMPOSITIONS AND KITS FOR TREATING, MODULATING, OR PREVENTING OCULAR ANGIOGENESIS OR FIBROSIS IN A SUBJECT USING A GALECTIN PROTEIN INHIBITOR<br/>[FR] MÉTHODES, COMPOSITIONS ET KITS DE TRAITEMENT, DE MODULATION OU DE PRÉVENTION DE L'ANGIOGENÈSE OU DE LA FIBROSE OCULAIRE CHEZ UN SUJET UTILISANT UN INHIBITEUR DE GALECTINE
  申请人：UNIV TUFTS

  公开号：WO2014078655A1

  公开（公告）日：2014-05-22

  Methods and kits using a pharmaceutical composition for use in inhibiting ocular angiogenesis or fibrosis are provided herein, such that composition includes a pharmaceutically suitable carrier or diluent and an amount of the inhibitor composition effective to inhibit the angiogenesis or the fibrosis by inhibiting expression and/or activity of a galectin protein or a portion thereof.

  本文提供了用于抑制眼部血管生成或纤维化的制药组合物的方法和试剂盒，该组合物包括一种药用合适载体或稀释剂和足以抑制血管生成或纤维化的抑制剂组合物的数量，通过抑制表达和/或活性的低聚半乳糖蛋白或其部分来抑制血管生成或纤维化。
• Electrochemical detection of microorganisms
  申请人：NANYANG TECHNOLOGICAL UNIVERSITY

  公开号：US10179927B2

  公开（公告）日：2019-01-15

  The present invention provides a method for determining the presence of a microorganism in a sample using an electrochemically active reporter, wherein the method comprises (a) contacting the sample with an electrochemically active reporter, wherein the electrochemically active reporter is a conjugate comprising a sugar moiety and a redox active reporter moiety that are covalently linked such that the covalent bond can be enzymatically cleaved in the presence of the microorganism by an enzyme expressed by the microorganism, wherein the redox active reporter moiety is selected from the group consisting of resorufin and compounds of formula (I) as defined herein, under conditions that allow enzymatic cleavage of the covalent bond between the sugar moiety and the redox active reporter moiety and reduction of the redox active report moiety in the presence of the microorganism; (b) electrochemically determining the released redox active reporter moiety; and (c) determining the presence of the microorganism and, optionally, number of the microorganisms in the sample based on the determined released redox active reporter moiety. Also encompassed are the electrochemically active reporters used in the described methods and their use for determination of the presence of microorganisms in a sample.

  本发明提供了一种使用电化学活性报告物确定样品中是否存在微生物的方法，其中该方法包括 (a) 将样品与电化学活性报告物接触，其中电化学活性报告物是一种共轭物，该共轭物包括共价连接的糖分子和氧化还原活性报告物分子，该共价键可在微生物存在的情况下由微生物表达的酶酶解、其中氧化还原活性报告分子选自由本文定义的 Resorufin 和式 (I) 化合物组成的组，在微生物存在的条件下，允许酶裂解糖分子和氧化还原活性报告分子之间的共价键并还原氧化还原活性报告分子；(b) 电化学测定释放的氧化还原活性报告分子；以及 (c) 根据测定的释放的氧化还原活性报告分子，确定样品中是否存在微生物以及微生物的数量。此外，还包括所述方法中使用的电化学活性报告子及其在确定样品中是否存在微生物时的用途。
• Digital polymerase fidelity assay
  申请人：Bio-Rad Laboratories, Inc.

  公开号：US10287620B2

  公开（公告）日：2019-05-14

  Methods of determining polymerase fidelity are provided. In one embodiment, the method comprises filling a gapped plasmid with a polymerase to form a gap-filled plasmid, wherein the gap-filled plasmid comprises a gene encoding an protein that is functional or non-functional depending on the polymerase fidelity; forming a plurality of partitions from a solution comprising the gap-filled plasmid and a label for detecting the presence of the plasmid; detecting the presence of the gap-filled plasmid in one or more of the partitions; and determining the fidelity of the polymerase by determining a ratio of partitions containing the gene encoding a functional protein to partitions containing a gene encoding a non-functional protein.

  本文提供了确定聚合酶保真度的方法。在一个实施方案中，该方法包括用聚合酶填充有间隙的质粒以形成填充有间隙的质粒，其中填充有间隙的质粒包含编码蛋白质的基因，该蛋白质根据聚合酶的保真度是功能性的或非功能性的；从包含填充有间隙的质粒和用于检测质粒存在的标签的溶液中形成多个分区；检测一个或多个分区中是否存在间隙填充质粒；以及通过确定含有编码功能性蛋白质的基因的分区与含有编码非功能性蛋白质的基因的分区之比来确定聚合酶的保真度。