N-[2-[4-[(氨基磺酰基)氧基]苯基]乙基]十四酰胺 | 186303-55-9

• 物质功能分类: 生物化工 - 抑制剂
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-[2-[4-[(氨基磺酰基)氧基]苯基]乙基]十四酰胺
• 英文名称: Sulfamic acid, 4-(2-((1-oxotetradecyl)amino)ethyl)phenyl ester
• 英文别名: [4-[2-(tetradecanoylamino)ethyl]phenyl] sulfamate
• CAS: 186303-55-9
• 化学式: C₂₂H₃₈N₂O₄S
• 分子量: 426.6
• InChiKey: MBODHUVGZPZRBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  29
• 可旋转键数：
  17
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  107
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Cyclic aminophenyl sulfamate derivative
  申请人：Takegawa Shigehiro

  公开号：US20060189625A1

  公开（公告）日：2006-08-24

  This invention provides cyclicamino-phenyl sulfamate derivatives represented by a formula wherein each of R 1 and R 2 stands for hydrogen or lower alkyl; each of R 3 and R 4 stands for hydrogen, halogen, cyano or the like; A stands for nitrogen or CH; B stands for CH 2 , SO 2 , CO, optionally substituted phenyl or the like; and R 5 stands for alkyl, phenyl, amino or the like, or salts thereof which exhibit excellent steroid sulfatase inhibitory activity and are useful for prevention or treatment of diseases associated with steroids such as estrogen, androgen and the like.

  本发明提供了一种循环氨基苯磺酰胺衍生物，其表示为以下式子： 其中，R1和R2中的每一个代表氢或低碳基；R3和R4中的每一个代表氢、卤素、氰或类似物；A代表氮或CH；B代表CH2、SO2、CO、可选取代的苯基或类似物；R5代表烷基、苯基、氨基或类似物，或其盐，具有出色的类固醇磺酸酶抑制活性，可用于预防或治疗与雌激素、雄激素等类固醇相关的疾病。
• SULFATED C19 STEROID HORMONES TO EXTEND LIFESPAN AND PROTECT AGAINST AGING-ASSOCIATED PROTEOTOXICITY
  申请人：Universidad Pablo de Olavide

  公开号：EP3988095A1

  公开（公告）日：2022-04-27

  The present invention is encompassed within the field of medicine and provides a composition for use in (a) a method for improving age-related cognitive function and/or treating disorders involving age-related cognitive dysfunction, or age-related cognitive impairment in a subject in need thereof; or (b) in a method of increasing the lifespan of a eukaryotic organism in a subject in need thereof.

  本发明属于医学领域，提供了一种组合物，可用于 (a) 改善有需要的受试者与年龄相关的认知功能和/或治疗涉及与年龄相关的认知功能障碍或与年龄相关的认知损害的疾病的方法；或 (b) 用于延长有需要的真核生物体寿命的方法。
• SULFATED C19 STEROID HORMONES TO TREAT AND/OR PREVENT PROTEOTOXICITY IN PROTEIN-AGGREGATION DISEASES
  申请人：Universidad Pablo de Olavide OTRI

  公开号：EP3988096A1

  公开（公告）日：2022-04-27

  The present invention is encompassed within the field of medicine and provides a composition for use in the treatments and/or prevention of protein-aggregation diseases.

  本发明属于医学领域，提供了一种用于治疗和/或预防蛋白质聚集疾病的组合物。
• CYCLIC AMINOPHENYL SULFAMATE DERIVATIVE
  申请人：ASKA Pharmaceutical Co., Ltd.

  公开号：EP1627871B1

  公开（公告）日：2010-04-14
• PHENYL SULFAMATE DERIVATIVES
  申请人：Teikoku Hormone Mfg. Co., Ltd.

  公开号：EP1193250B1

  公开（公告）日：2008-06-04