N-[3',6'-二(BETA-D-吡喃半乳糖基氧基)-3-氧代螺[异苯并呋喃-1(3H),9'-[9H]氧杂蒽]-5-基]十二烷酰胺 | 138777-25-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: N-[3',6'-二(BETA-D-吡喃半乳糖基氧基)-3-氧代螺[异苯并呋喃-1(3H),9'-[9H]氧杂蒽]-5-基]十二烷酰胺
• 中文别名: 5-十二酰氨基荧光素-二-β-D-吡喃半乳糖苷
• 英文名称: C₁₂FDG
• 英文别名: N-[3',6'-Bis(beta-D-galactopyranosyloxy)-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl]dodecanamide；N-[3-oxo-3',6'-bis[[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]spiro[2-benzofuran-1,9'-xanthene]-5-yl]dodecanamide
• CAS: 138777-25-0
• 化学式: C₄₄H₅₅NO₁₆
• 分子量: 853.918
• InChiKey: SLIWIQKBDGZFQR-PIVCGYGYSA-N

物化性质

• 沸点：
  1076.0±65.0 °C(Predicted)
• 密度：
  1.49±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  61
• 可旋转键数：
  17
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  263
• 氢给体数：
  9
• 氢受体数：
  16

文献信息

• Methylation signature for replicative senescence of cells in culture
  申请人：Rheinisch-Westfälisch-Technische Hochschule Aachen

  公开号：EP2554678A1

  公开（公告）日：2013-02-06

  The invention concerns methods and kits for determining the replicative senescence status of a cell, for identifying a cell culture which is suitable for therapeutic use, and for quantifying the reprogramming efficiency of induced pluripotent stem cells, wherein the methylation status of at least one of the CpG-dinucleotides within a region of about 100,000 bp upstream and/or downstream of at least one of the CpG-dinucleotides selected from the group consisting of GRM7-CpG-site #1, CASR-CpG-site #1, PRAMEF2-CpG-site #1, SELP-CpG-site #1, CASP14-CpG-site #1 and KRTAP13-3-CpG-site #1 for multiple corresponding DNA molecules is determined and compared to a reference methylation status.

  本发明涉及用于确定细胞复制衰老状态、鉴定适合治疗用途的细胞培养物以及量化诱导多能干细胞重编程效率的方法和试剂盒，其中在约100、000bp上游和/或下游的至少一个CpG-核苷酸的甲基化状态，这些CpG-核苷酸选自多个相应DNA分子的GRM7-CpG-位点＃1、CASR-CpG-位点＃1、PRAMEF2-CpG-位点＃1、SELP-CpG-位点＃1、CASP14-CpG-位点＃1和KRTAP13-3-CpG-位点＃1组成的组。
• Antibodies to human erythroferrone and uses thereof
  申请人：Intrinsic LifeSciences LLC

  公开号：US10604567B2

  公开（公告）日：2020-03-31

  Disclosed herein are antibodies specific for erythroferrone and assays comprising the antibodies. Also disclosed are methods for using the assays for the diagnosis or monitoring of disease.

  本文公开了针对红铁酮的特异性抗体以及包含该抗体的检测方法。还公开了使用这些检测方法诊断或监测疾病的方法。
• Microfluidic devices and methods for use thereof in multicellular assays of secretion
  申请人：The University of British Columbia

  公开号：US10725024B2

  公开（公告）日：2020-07-28

  Methods and devices are provided herein for identifying a cell population comprising an effector cell that exerts an extracellular effect. In one embodiment the method comprises retaining in a microreactor a cell population comprising one or more effector cells, wherein the contents of the microreactor further comprise a readout particle population comprising one or more readout particles, incubating the cell population and the readout particle population within the microreactor, assaying the cell population for the presence of the extracellular effect, wherein the readout particle population or subpopulation thereof provides a direct or indirect readout of the extracellular effect, and determining, based on the results of the assaying step, whether one or more effector cells within the cell population exerts the extracellular effect on the readout particle. If an extracellular effect is measured, the cell population is recovered for further analysis to determine the cell or cells responsible for the effect.

  本文提供了用于鉴定细胞群的方法和装置，该细胞群包括产生细胞外效应的效应细胞。在一个实施方案中，该方法包括在微反应器中保留包含一个或多个效应细胞的细胞群，其中微反应器的内容物进一步包含包含一个或多个读出粒子的读出粒子群，在微反应器中培养细胞群和读出粒子群、检测细胞群是否存在细胞外效应，其中读出粒子群或其亚群提供细胞外效应的直接或间接读出，并根据检测步骤的结果确定细胞群中的一个或多个效应细胞是否对读出粒子产生细胞外效应。如果测得细胞外效应，则回收细胞群进行进一步分析，以确定产生效应的细胞。
• A GENETICALLY ENGINEERED CELL LINE FOR DETECTING INFECTIOUS HERPES SIMPLEX VIRUS AND METHOD THEREFOR
  申请人：WASHINGTON UNIVERSITY

  公开号：EP0646124A1

  公开（公告）日：1995-04-05
• EP0646124A4
  申请人：——

  公开号：EP0646124A4

  公开（公告）日：1996-10-23