5-Acetamido-4-hydroxy-2-methoxy-6-(1,2,3-trihydroxypropyl)oxane-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-Acetamido-4-hydroxy-2-methoxy-6-(1,2,3-trihydroxypropyl)oxane-2-carboxylic acid
• 化学式: C₁₂H₂₁NO₉
• 分子量: 323.3
• InChiKey: NJRVVFURCKKXOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  166
• 氢给体数：
  6
• 氢受体数：
  9

文献信息

• Heterobifunctional pan-selectin inhibitors
  申请人：Magnani L. John

  公开号：US20070054870A1

  公开（公告）日：2007-03-08

  Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).

  提供了用于调节体外和体内由选择素结合介导的过程的化合物和方法。更具体地描述了选择素调节剂及其用途，其中调节选择素介导功能的选择素调节剂包括特定的糖类似物，单独或与一类被称为BASAs（苯甲基氨基磺酸）的化合物或一类被称为BACAs（苯甲基氨基羧酸）的化合物中的成员相连。
• Heterobifunctional compounds for selectin inhibition
  申请人：Magnani John L.

  公开号：US20090036386A1

  公开（公告）日：2009-02-05

  Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise glycomimetics linked to a compound, for example a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
• ANTIVIRAL COMPOUNDS
  申请人：Veronesi Paolo Alberto

  公开号：US20100029579A1

  公开（公告）日：2010-02-04

  The invention provides a new class of compounds exhibiting an inhibitory effect on neuraminidase (NA), hemagglutinin (HA) and structural M 2 protein bearing viruses. These compounds are also useful as inhibitors of the replication factors of hepatitis virus type C (HVC). The invention also describes pharmaceutical compositions containing the compounds of the invention either alone or in combination admixed with a suitable and pharmaceutically acceptable carrier.
• HETEROBIFUNCTIONAL PAN-SELECTIN INHIBITORS
  申请人：MAGNANI John L.

  公开号：US20100204170A1

  公开（公告）日：2010-08-12

  Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
• TREATMENT AND PROPHYLAXIS
  申请人：Levesque Jean-Pierre

  公开号：US20110020270A1

  公开（公告）日：2011-01-27

  This invention discloses the use of an E-selectin antagonist and a mobilizer of hematopoietic stem cells or progenitor cells in methods and compositions for treating or preventing immunocompromised conditions resulting from medical treatment. The present invention is particular relevant for prophylaxis and/or treatment of hematopoeitic disorders including neutropenia, agranulocytosis, anemia and thrombocytopenia in individuals receiving or proposed to receive treatments that target rapidly dividing cells or that disrupt the cell cycle or cell division.