Methyl 3,4,5-tris(acetyloxy)-6-azidooxane-2-carboxylate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Methyl 3,4,5-tris(acetyloxy)-6-azidooxane-2-carboxylate
• 英文别名: methyl 3,4,5-triacetyloxy-6-azidooxane-2-carboxylate
• 化学式: C13H17N3O9
• 分子量: 359.29
• InChiKey: PMUZMIKGOMUGFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  129
• 氢给体数：
  0
• 氢受体数：
  11

文献信息

• WATER SOLUBLE POLYFLUORENE FUNCTIONALIZED WITH GLUCURONIC ACID USEFUL IN BILIRUBIN SENSING
  申请人：COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

  公开号：US20160169917A1

  公开（公告）日：2016-06-16

  The present invention provide water soluble polyfluorenes functionalized with glucuronic acid useful in sensing bilirubin in aqueous medium and process for preparation thereof. The invention further deals with detecting bilirubin in human serum samples in the range from normal (<25 μηioI/L˜1.2 mg/dL) human bilirubin level to jaundiced bilirubin level (>50 μηioI/L˜2.5 mg/dL). This is a fluorescence turn-off mode of detection where blue fluorescence of polymer quenches and becomes colorless. The water soluble polyfluorenes functionalized with glucuronic acid can detect free bilirubin in the range from 1×1O″4M to 1×10′7M moles in aqueous and buffer media as a change in the fluorescence signal.

  本发明提供了一种功能化葡萄糖醛酸的水溶性聚芴，可用于在水介质中感测胆红素，并提供了其制备方法。本发明进一步涉及检测人血清样品中的胆红素，范围从正常（<25μηioI/L˜1.2 mg/dL）的人类胆红素水平到黄疸的胆红素水平（>50μηioI/L˜2.5 mg/dL）。这是一种荧光熄灭检测模式，其中聚合物的蓝色荧光被熄灭并变为无色。功能化葡萄糖醛酸的水溶性聚芴可以在水和缓冲介质中检测1×10^-4M至1×10^-7M摩尔范围内的游离胆红素，作为荧光信号的变化。
• Water Soluble Polymer Surfactant for Synthesis of Functionalized Polystyrene Nanobeads Towards Detection of Bilirubin in Human Serum
  申请人：Council of Scientific & Industrial Research

  公开号：US20210255206A1

  公开（公告）日：2021-08-19

  The present invention provides a water soluble polymer surfactant (PS-DGlu) of formula I which is utilized for synthesis of functionalized polystyrene nanobead covalently incorporating (oligo) p-phenylenevinylene (OPV) nanosensor (PSG-OPV-n) which in turn is useful for the detection of bilirubin in human serum. The present invention further provides a process for the preparation of the water soluble polymer surfactant (PS-DGlu) of formula (I) and a mini emulsion polymerization process for the synthesis of PSG-OPV-n. wherein, n is 30-50. The PSG-OPV-n nanosensor beads show selectivity towards detection of bilirubin in presence of interferences such as glucose, sucrose, metal ions, cholesterol, and biliverdin with limit of detection of 20 nM. Ultimately, the invention also provides a kit for visual detection of bilirubin in human serum.
• US9915669B2
  申请人：——

  公开号：US9915669B2

  公开（公告）日：2018-03-13
• [EN] WATER SOLUBLE POLYFLUORENE FUNCTIONALIZED WITH GLUCURONIC ACID USEFUL IN BILIRUBIN SENSING<br/>[FR] POLYFLUORÈNE HYDROSOLUBLE FONCTIONNALISÉ AVEC L'ACIDE GLUCURONIQUE UTILE DANS LA DÉTECTION DE LA BILIRUBINE
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2015015517A1

  公开（公告）日：2015-02-05

  The present invention provide water soluble polyfluorenes functionalized with glucuronic acid useful in sensing bilirubin in aqueous medium and process for preparation thereof. The invention further deals with detecting bilirubin in human serum samples in the range from normal (< 25 μηιοΙ/L ~ 1.2 mg/dL) human bilirubin level to jaundiced bilirubin level (> 50 μηιοΙ/L ~ 2.5mg/dL). ' This is a fluorescence turn-off mode of detection where blue fluorescence of polymer quenches and becomes colorless. The water soluble polyfluorenes functionalized with glucuronic acid can detect free bilirubin in the range from lxlO"4M to lx 10'7M moles in aqueous and buffer media as a change in the fluorescence signal.