(R)-2-tert-Butoxycarbonylamino-octadecanoic acid | 510730-72-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (R)-2-tert-Butoxycarbonylamino-octadecanoic acid
• 英文别名: (2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]octadecanoic acid
• CAS: 510730-72-0
• 化学式: C₂₃H₄₅NO₄
• 分子量: 399.615
• InChiKey: UGRVSCNUONHHST-HXUWFJFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  28
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (R)-2-tert-Butoxycarbonylamino-octadecanoic acid 在 盐酸 作用下， 反应 1.0h， 生成 (R)-2-Amino-octadecanoic acid; hydrochloride
  参考文献：
  名称：

  Synthesis of chiral α-amino acids

  摘要：

  A novel method for the synthesis of chiral alpha-amino acids has been developed where the acid functionality was constructed by oxidizing a hydroxymethyl group introduced by Evans' method in the alpha-position of an appropriate acid substrate and the amino part came from the amide of the original carboxyl group following a modified Hofmann rearrangement reaction. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(02)02433-4
• 作为产物：
  描述：

  tert-butyl N-[(2R)-1-phenylmethoxyoctadecan-2-yl]carbamate 在 palladium dihydroxide ruthenium trichloride 、 sodium periodate 、 氢气 作用下， 以 甲醇 、 四氯化碳 、 水 、 乙腈 为溶剂， 反应 5.0h， 生成 (R)-2-tert-Butoxycarbonylamino-octadecanoic acid
  参考文献：
  名称：

  Synthesis of chiral α-amino acids

  摘要：

  A novel method for the synthesis of chiral alpha-amino acids has been developed where the acid functionality was constructed by oxidizing a hydroxymethyl group introduced by Evans' method in the alpha-position of an appropriate acid substrate and the amino part came from the amide of the original carboxyl group following a modified Hofmann rearrangement reaction. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(02)02433-4

文献信息

• [EN] DELIVERY SYSTEMS<br/>[FR] SYSTEMES D'ADMINISTRATION
  申请人：ALCHEMIA PTY LTD

  公开号：WO2002053572A1

  公开（公告）日：2002-07-11

  The invention relates to compounds which are useful in the delivery of a wide variety of therapeutically useful molecules. In particular, the invention relates to compounds which are able to act as carriers for therapeutically useful molecules, and to pharmaceutical agents comprising these carriers. The compounds of the invention comprise a mono- or oligosaccharide, a lipidic moiety, and optionally a linker and/or a spacer. The pharmaceutical agents of the invention are particularly useful for oral administration.
• Synthesis of chiral α-amino acids
  作者：Tushar K Chakraborty、Animesh Ghosh

  DOI：10.1016/s0040-4039(02)02433-4

  日期：2002.12

  A novel method for the synthesis of chiral alpha-amino acids has been developed where the acid functionality was constructed by oxidizing a hydroxymethyl group introduced by Evans' method in the alpha-position of an appropriate acid substrate and the amino part came from the amide of the original carboxyl group following a modified Hofmann rearrangement reaction. (C) 2002 Published by Elsevier Science Ltd.