(5-morpholin-4-yl-4-phenyl-thiophen-2-yl)-phenyl-methanone | 86673-60-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (5-morpholin-4-yl-4-phenyl-thiophen-2-yl)-phenyl-methanone
• 英文别名: [5-(Morpholin-4-yl)-4-phenylthiophen-2-yl](phenyl)methanone；(5-morpholin-4-yl-4-phenylthiophen-2-yl)-phenylmethanone
• CAS: 86673-60-1
• 化学式: C₂₁H₁₉NO₂S
• 分子量: 349.453
• InChiKey: NLEDJYSFYRSVAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  57.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-[3-(4-morpholinyl)-2-phenyl-1-thioxo-2-propenyl]morpholine 在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 3.0h， 生成 (5-morpholin-4-yl-4-phenyl-thiophen-2-yl)-phenyl-methanone
  参考文献：
  名称：

  Synthesis and characterisation of N,N-disubstituted 2-amino-5-acylthiophenes and 2-amino-5-acylthiazoles

  摘要：

  Starting from halomethyl-ketones 8 and N,N'-persubstituted thioacrylamides 7 or their 2-aza analogues 11 a series of N,N-disubstituted 2-amino-5-acylthiophenes 10 and 2-amino-5-acylthiazoles 12, respectively are available. By starting from 1,3-dichloroacetone and using the same thioacrylamide derivatives 7 and 11 N,N-disubstituted 2-amino-5-(chloroacetyl)thiophenes 13 and 2-amino-5-(chloroacetyl)thiazoles 14 as well as N,N'-persubstituted bis-(2-amino-5-thienyl)ketones 15, 2-amino-5-thienyl-(2-amino-5-thiazolyl)ketones 16, and bis-(2-amino-5-thiazolyl)ketones 17, respectively are available. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)00083-2

文献信息

• Liebscher, Juergen; Abegaz, Berhanu; Areda, Alemayehu, Journal fur praktische Chemie (Leipzig 1954), 1983, vol. 325, # 1, p. 168 - 172
  作者：Liebscher, Juergen、Abegaz, Berhanu、Areda, Alemayehu

  DOI：——

  日期：——
• Solvent-Free Synthesis of 2-Amino-3-aryl-5-substituted Thiophenes as Anti-inflammatory Agents using KF-Al₂O₃ under Microwave Irradiation
  作者：Hamdollah Saeidian、Azam Sadeghi、Zohreh Mirjafary、Firouz Matloubi Moghaddam

  DOI：10.1080/00397910801997843

  日期：2008.5.23

  The synthesis of 2-amino-3-aryl-5-substituted thiophenes as anti-inflammatory agents catalyzed by KF-Al2O3 under microwave irradiation is reported.
• LIEBSCHER, J.;ABEGAZ, BERHANU;AREDA, ALEMAYEHU, J. PRAKT. CHEM., 1983, 325, N 1, 168-172
  作者：LIEBSCHER, J.、ABEGAZ, BERHANU、AREDA, ALEMAYEHU

  DOI：——

  日期：——
• THIAZOLE AND THIOPHENE ANALOGUES, AND THEIR USE IN TREATING AUTOIMMUNE DISEASES AND CANCERS
  申请人：Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College

  公开号：EP2007393A2

  公开（公告）日：2008-12-31
• Thiazole and Thiophene Analogues, and Their Use in Treating Autoimmune Diseases and Cancers
  申请人：Giordano Anthony

  公开号：US20090306073A1

  公开（公告）日：2009-12-10

  Thiazole and thiophene compounds are disclosed having utility in treating inflammatory conditions, immunoinflammatory conditions, autoimmune diseases, and cancers. Methods for the synthesis of these compounds are also disclosed.