Trifluoro-methanesulfonic acid (1S,4R,6S)-4-(tert-butyl-dimethyl-silanyloxy)-7-oxa-bicyclo[4.1.0]hept-2-en-2-yl ester | 224630-71-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: Trifluoro-methanesulfonic acid (1S,4R,6S)-4-(tert-butyl-dimethyl-silanyloxy)-7-oxa-bicyclo[4.1.0]hept-2-en-2-yl ester
• 英文别名: [(1S,4R,6S)-4-[tert-butyl(dimethyl)silyl]oxy-7-oxabicyclo[4.1.0]hept-2-en-2-yl] trifluoromethanesulfonate
• CAS: 224630-71-1
• 化学式: C₁₃H₂₁F₃O₅SSi
• 分子量: 374.453
• InChiKey: NAWJSTTVUWQVDW-YWVKMMECSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  73.5
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  Trifluoro-methanesulfonic acid (1S,4R,6S)-4-(tert-butyl-dimethyl-silanyloxy)-7-oxa-bicyclo[4.1.0]hept-2-en-2-yl ester 在 咪唑 作用下， 以 乙腈 为溶剂， 反应 18.0h， 生成 Trifluoro-methanesulfonic acid (3R,5S,6R)-6-azido-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-cyclohex-1-enyl ester
  参考文献：
  名称：

  Synthesis of 6-carbon termini-differentiated stereotriads via symchiral 2-trifloxy-1,3-cyclohexadiene monoepoxide

  摘要：

  Jacobsen epoxidation of 2-trifloxy-1,3-cyclohexadiene provides a valuable asymmetric monoepoxide product that can be readily manipulated to efficiently provide highly-functionalized symchiral cyclic and acyclic synthons. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00343-3
• 作为产物：
  描述：

  cyclohexa-2,4-dienyl trifluoromethanesulfonate 在 双氧水 、 甲基三氧化铼(VII) 、 lithium hexamethyldisilazane 作用下， 以 六甲基磷酰三胺 为溶剂， 生成 Trifluoro-methanesulfonic acid (1S,4R,6S)-4-(tert-butyl-dimethyl-silanyloxy)-7-oxa-bicyclo[4.1.0]hept-2-en-2-yl ester
  参考文献：
  名称：

  Synthesis of 6-carbon termini-differentiated stereotriads via symchiral 2-trifloxy-1,3-cyclohexadiene monoepoxide

  摘要：

  Jacobsen epoxidation of 2-trifloxy-1,3-cyclohexadiene provides a valuable asymmetric monoepoxide product that can be readily manipulated to efficiently provide highly-functionalized symchiral cyclic and acyclic synthons. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00343-3

文献信息

• Synthesis of 6-carbon termini-differentiated stereotriads via symchiral 2-trifloxy-1,3-cyclohexadiene monoepoxide
  作者：Murphy Hentemann、P.L. Fuchs

  DOI：10.1016/s0040-4039(99)00343-3

  日期：1999.4

  Jacobsen epoxidation of 2-trifloxy-1,3-cyclohexadiene provides a valuable asymmetric monoepoxide product that can be readily manipulated to efficiently provide highly-functionalized symchiral cyclic and acyclic synthons. (C) 1999 Elsevier Science Ltd. All rights reserved.