2-methoxy-4-{[2-(1-methyl-1H-2-imidazolyl)thieno[3,2-b]pyridin-7-yl]oxy}aniline | 875340-28-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-methoxy-4-{[2-(1-methyl-1H-2-imidazolyl)thieno[3,2-b]pyridin-7-yl]oxy}aniline
• 英文别名: 2-Methoxy-4-(2-(1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)benzenamine；2-methoxy-4-[2-(1-methylimidazol-2-yl)thieno[3,2-b]pyridin-7-yl]oxyaniline
• CAS: 875340-28-6
• 化学式: C₁₈H₁₆N₄O₂S
• 分子量: 352.417
• InChiKey: OWISVGFVTHONKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  103
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-methoxy-4-{[2-(1-methyl-1H-2-imidazolyl)thieno[3,2-b]pyridin-7-yl]oxy}aniline 、 二吡啶硫碳酸酯 以 氯仿 为溶剂， 反应 1.0h， 生成 2-methoxy-4-{[2-(1-methyl-1H-2-imidazolyl)thieno[3,2-b]pyridin-7-yl]oxy}phenylisothiocyanate
  参考文献：
  名称：

  EP1870414

  摘要：

  公开号：

文献信息

• [EN] INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING<br/>[FR] INHIBITEURS DE SIGNALISATION DE RECEPTEUR DU FACTEUR DE CROISSANCE ENDOTHELIALE (VEGF) ET DE RECEPTEUR DE FACTEUR DE CROISSANCE DES HEPATOCYTES (HGF)
  申请人：METHYLGENE INC

  公开号：WO2006010264A1

  公开（公告）日：2006-02-02

  The invention relates to the inhibition of vascular endothelial growth factor (VEGF) receptor signaling and hepatocyte growth factor (HGF) receptor signaling. The invention provides compounds and methods for inhibiting VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions

  该发明涉及抑制血管内皮生长因子（VEGF）受体信号和肝细胞生长因子（HGF）受体信号的方法。该发明提供了抑制VEGF受体信号和HGF受体信号的化合物和方法。该发明还提供了治疗细胞增殖性疾病和症状的组合物和方法。
• INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING
  申请人：Saavedra Mario Oscar

  公开号：US20060287343A1

  公开（公告）日：2006-12-21

  The invention relates to the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention provides compounds and methods for inhibiting VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions

  本发明涉及抑制VEGF受体信号和HGF受体信号的方法。本发明提供了抑制VEGF受体信号和HGF受体信号的化合物和方法。本发明还提供了用于治疗细胞增殖性疾病和病状的组合物和方法。
• Inhibitors of VEGF receptor and HGF receptor signaling
  申请人：Vaisburg Arkadii

  公开号：US20060074056A1

  公开（公告）日：2006-04-06

  The invention relates to the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention provides compounds and methods for inhibiting VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions

  本发明涉及抑制VEGF受体信号和HGF受体信号的方法。本发明提供了抑制VEGF受体信号和HGF受体信号的化合物和方法。本发明还提供了治疗细胞增殖性疾病和病状的组合物和方法。
• THIENOPYRIDINE DERIVATIVE, OR QUINOLINE DERIVATIVE, OR QUINAZOLINE DERIVATIVE, HAVING c-MET AUTOPHOSPHORYLATION INHIBITING POTENCY
  申请人：Kubo Kazuo

  公开号：US20090270391A1

  公开（公告）日：2009-10-29

  An objective of the present invention is to provide compounds having antitumor activity. According to the present invention, there is provided compounds represented by formula (I) and pharmaceutically acceptable salts thereof, and solvates thereof: wherein R 1 represents H or a substitutable unsaturated five- or six-membered heterocyclic ring; R 2 represents H; X represents CH or N; Z represents O or S; E is absent or represents halogen, alkyl, or alkoxy; J represents S or O; and T represents phenyl, an unsaturated five- or six-membered heterocyclic ring, an unsaturated nine- or ten-membered bicyclic carbocyclic ring or heterocyclic ring.

  本发明的目标是提供具有抗肿瘤活性的化合物。根据本发明，提供了由公式（I）表示的化合物及其药学上可接受的盐和溶剂化物：其中，R1代表H或可取代的不饱和五元或六元杂环环；R2代表H；X代表CH或N；Z代表O或S；E不存在或代表卤素，烷基或烷氧基；J代表S或O；T代表苯基，不饱和五元或六元杂环环，不饱和九元或十元双环碳环或杂环环。
• Inhibitors of VEGF Receptor and HGF Receptor Signalling
  申请人：Vaisburg Arkadii

  公开号：US20100216766A1

  公开（公告）日：2010-08-26

  The invention relates to the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention provides compounds and methods for inhibiting VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions

  本发明涉及抑制VEGF受体信号和HGF受体信号的方法。本发明提供了抑制VEGF受体信号和HGF受体信号的化合物和方法。本发明还提供了治疗细胞增殖性疾病和病症的组合物和方法。