8-Chloro-5,10-dihydro-indeno[1,2-b]indole | 875896-18-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 8-Chloro-5,10-dihydro-indeno[1,2-b]indole
• 英文别名: 8-Chloro-5,10-dihydroindeno[1,2-b]indole；8-chloro-5,10-dihydroindeno[1,2-b]indole
• CAS: 875896-18-7
• 化学式: C₁₅H₁₀ClN
• 分子量: 239.704
• InChiKey: MGTUQZFDTBWPEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  15.8
• 氢给体数：
  1
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  8-Chloro-5,10-dihydro-indeno[1,2-b]indole 在 盐酸 、 dimethyl sulfide borane 、 间氯过氧苯甲酸 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 生成 (Z)-2-Chloro-5,6-dihydro-dibenzo[b,f]azocine
  参考文献：
  名称：

  Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17β-hydroxysteroid dehydrogenase type 3

  摘要：

  A novel series of 17 beta-hydroxysteroid dehydrogenase type 3 (17 beta-HSD3) inhibitors has been identified. These inhibitors, based on a dibenzazocine core, exhibited picomolar to low nanomolar inhibition of 17 beta-HSD3 in cell-free enzymatic as well as in cell-based transcriptional reporter assays. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.12.039
• 作为产物：
  描述：

  N-(4-Chloro-phenyl)-N'-indan-(1E)-ylidene-hydrazine 在 硫酸 、 溶剂黄146 作用下， 以 甲苯 为溶剂， 生成 8-Chloro-5,10-dihydro-indeno[1,2-b]indole
  参考文献：
  名称：

  Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17β-hydroxysteroid dehydrogenase type 3

  摘要：

  A novel series of 17 beta-hydroxysteroid dehydrogenase type 3 (17 beta-HSD3) inhibitors has been identified. These inhibitors, based on a dibenzazocine core, exhibited picomolar to low nanomolar inhibition of 17 beta-HSD3 in cell-free enzymatic as well as in cell-based transcriptional reporter assays. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.12.039

文献信息

• A Tandem Oxidative Annulation Strategy for the Synthesis of Tetracyclic 3-Spirooxindole Benzofuranones
  作者：Chunxia Zhang、Min Liu、Mingruo Ding、Hao Xie、Fengzhi Zhang

  DOI：10.1021/acs.orglett.7b01374

  日期：2017.7.7

  efficient method was developed for the construction of the medicinally important tetracyclic 3-spirooxindole benzofuranones. In this highly atom- and step-economical one-pot protocol, one quaternary carbon center, two new cycles, and four new bonds (C–C/C–O/C–N) were formed under simple ligand-free copper-catalyzed conditions through a novel tandem oxidative annulation strategy.

  开发了一种简单有效的方法来构建具有医学重要性的四环3-螺氧并恶唑苯并呋喃酮。在这种高度原子和步骤经济的一锅方案中，在简单的无配体铜催化下形成了一个季碳中心，两个新环和四个新键（CC-C / C-O / C-N）通过新型串联氧化环化策略获得的条件。