3-Fluorsulfonyl-phenacylbromid | 455-82-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-Fluorsulfonyl-phenacylbromid
• 英文别名: 3-bromoacetyl-benzenesulfonyl fluoride；m-fluorosulfonylphenacyl bromide；Benzenesulfonyl fluoride, 3-(bromoacetyl)-；3-(2-bromoacetyl)benzenesulfonyl fluoride
• CAS: 455-82-3
• 化学式: C₈H₆BrFO₃S
• 分子量: 281.102
• InChiKey: LGOFPHDFCAXPRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  59.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-Fluorsulfonyl-phenacylbromid 以 1,4-二氧六环 、 乙醇 为溶剂， 生成 3-{2-[3-(3-nitro-phenyl)-3-oxo-propionylamino]-thiazol-4-yl}-benzenesulfonyl fluoride
  参考文献：
  名称：

  Sulfonyl Fluorides as Intermediates in Organic Synthesis. II. Synthesis and Alkaline Hydrolysis of 2-(Acylacetyl)aminothiazoles Containing Fluorosulfonyl Substituents

  摘要：

  DOI：

  10.1021/jo01016a038

文献信息

• The synthesis of substituted 2-aminothiazoles
  作者：Yang-i Lin、C. M. Seifert、S. M. Kang、J. P. Dusza、S. A. Lang

  DOI：10.1002/jhet.5570160718

  日期：1979.11

  The preparation of 4- and 5-acyl- and aroyl-2-substituted aminothiazoles is described. The condensation of thioureas with acyl halides leading to 4,5-disubstituted-2-aminothiazoles and 7-(4H)benzothiazolones is discussed. A discussion of the isolation of various intermediates and the mechanistic pathway is also included. A number of 2-anilino or 2-benzyl-4- or 5-aroylthiazoles possessed moderate oral

  描述了4-和5-酰基-和芳酰基-2-取代的氨基噻唑的制备。讨论了硫脲与酰基卤的缩合生成4,5-二取代-2-氨基噻唑和7-（4 H）苯并噻唑酮。还包括各种中间体的分离和机理途径的讨论。许多2-苯胺基或2-苄基-4-或5-芳酰基噻唑具有中等的口服抗结核活性（2）。
• [EN] IMIDAZO[2,1]THIAZOL-3-ONE DERIVATIVES USEFUL AS DIAGNOSTIC AGENTS FOR ALZHEIMER'S DISEASE<br/>[FR] DÉRIVÉS IMIDAZO[2,1]THIAZOL-3-ONE UTILES COMME AGENTS DE DIAGNOSTIC DE LA MALADIE D'ALZHEIMER
  申请人：HOFFMANN LA ROCHE

  公开号：WO2014026881A1

  公开（公告）日：2014-02-20

  The invention relates to imidazo[2,1-b]thiazol-3-one derivatives of formula (I) wherein the variables are as defined in the claims. It has been shown that the present compounds may be used for binding and imaging tau aggregates and related b-sheet aggregates including besides others beta-amyloid aggregates or alpha-synuclein aggregates, especially for use in binding and imaging tau aggregates in Alzheimer patients.

  该发明涉及式(I)中变量定义如权利要求中的咪唑[2,1-b]噻唑-3-酮衍生物。已经证明，这些化合物可用于结合和成像tau聚集体和相关的b-折叠聚集体，包括除其他外beta-淀粉样蛋白聚集体或α-突触核蛋白聚集体，特别是用于结合和成像阿尔茨海默病患者中的tau聚集体。
• Imidazo[2,1]thiazol-3-one derivatives
  申请人：Hoffmann-La Roche Inc.

  公开号：US20150157739A1

  公开（公告）日：2015-06-11

  The invention relates to imidazo[2,1-b]thiazol-3-one derivatives of formula wherein the variables are defined herein, or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof. It has been shown that the present compounds may be used for binding and imaging tau aggregates and related b-sheet aggregates including besides others beta-amyloid aggregates or alpha-synuclein aggregates, especially for use in binding and imaging tau aggregates in Alzheimer's patients.

  本发明涉及以下式子的咪唑[2,1-b]噻唑-3-酮衍生物，其中变量在此定义，或者其药学上可接受的酸加成盐，外消旋混合物或其对应的对映体和/或光学异构体。已经证明，这些化合物可以用于结合和成像tau聚集体和相关的β-折叠聚集体，包括除其他外的β-淀粉样聚集体或α-突触核蛋白聚集体，特别适用于在阿尔茨海默病患者中结合和成像tau聚集体。
• Photographic products and processes employing novel nondiffusible
  申请人：Eastman Kodak Company

  公开号：US04396546A1

  公开（公告）日：1983-08-02

  Photographic elements, diffusion transfer assemblages and processes are described which employ a novel nondiffusible compound having a releasable 6-(2-thienylazo)-3-pyridinol cyan dye moiety or precursor thereof, the compound containing: (a) in the 3-position of the thienylazo moiety a carboxy group, a salt thereof or a hydrolyzable precursor thereof; and (b) a ballasted carrier moiety which is capable of releasing the diffusible 6-(2-thienylazo)-3-pyridinol dye moiety or precursor thereof under alkaline conditions.

  本文描述了一种使用新型不可扩散化合物的摄影元素、扩散转移组件和过程，该化合物具有可释放的6-(2-噻吩基偶氮)-3-吡啶醇青染料基团或其前体，该化合物包含：(a)在噻吩基偶氮基团的3位上有一个羧基、其盐或可水解的前体；和(b)一个能够在碱性条件下释放可扩散的6-(2-噻吩基偶氮)-3-吡啶醇染料基团或其前体的配载体基团。
• Preparation of thiophenes
  申请人：Eastman Kodak Company

  公开号：US04447624A1

  公开（公告）日：1984-05-08

  Process for the preparation of thiophenes having the structure ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 can be various substituents. The compounds can be converted to the corresponding 2-amino compounds from which azo dyes can be prepared.

  制备具有结构##STR1##的噻吩的过程，其中R.sup.1，R.sup.2，R.sup.3和R.sup.4可以是不同的取代基。这些化合物可以转化为相应的2-氨基化合物，从而可以制备偶氮染料。