2-benzotriazol-2-yl-4-chloro-phenol | 4184-70-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-benzotriazol-2-yl-4-chloro-phenol
• 英文别名: 4-chloro-2-benzotriazo-2-yl-phenol；2-Benzotriazole-2-yl-4-chloro-phenol；2-(benzotriazol-2-yl)-4-chlorophenol
• CAS: 4184-70-7
• 化学式: C₁₂H₈ClN₃O
• 分子量: 245.668
• InChiKey: RBZKTWNFYPAGKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [4-(3-bromo-propylsulfanyl)-2-methyl-phenoxy]-acetic acid ethyl ester 、 2-benzotriazol-2-yl-4-chloro-phenol 在 caesium carbonate 作用下， 以 乙腈 为溶剂， 反应 4.0h， 生成 {4-[3-(2-benzotriazol-2-yl-4-chloro-phenoxy)-propylsulfanyl]-2-methyl-phenoxy}-acetic acid ethyl ester
  参考文献：
  名称：

  [EN] MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION
  [FR] MODULATEURS DE PPAR ET LEURS METHODES DE PREPARATION

  摘要：

  公开号：

  WO2006020916A3

文献信息

• N-[2-hydroxy-3-(2H-benzotriazol-2-yl)benzyl]oxamides as light stabilisers
  申请人：ELF ATOCHEM NORTH AMERICA, INC.

  公开号：EP0593936A1

  公开（公告）日：1994-04-27

  This invention relates to novel UV absorbers, their methods of preparation, their use in stabilizing polymers and polymers so stabilized against the degradative effects of UV light. The novel compounds of formula I are oxamides which are substituted on one or both nitrogens with a 2-hydroxy-3-(2H-benzotriazol-2-yl)benzyl group. The 2-hydroxy-3-(2H-benzotriazol-2-yl)benzyl groups are efficient UV absorbing groups and the oxamide group contributes additional light stabilizing, heat stabilizing and metal complexing properties to the compounds. The compounds have low-volatility and are especially useful as UV stabilizers for engineering resins processed at high temperatures.

  这项发明涉及新型紫外线吸收剂，其制备方法，其在稳定聚合物中的使用以及通过紫外线光的降解作用而得到稳定的聚合物。公式I的新型化合物是氧酰胺，其在一个或两个氮上被2-羟基-3-(2H-苯并三唑-2-基)苯甲基基团取代。2-羟基-3-(2H-苯并三唑-2-基)苯甲基基团是高效的紫外线吸收基团，而氧酰胺基团则为化合物提供了额外的光稳定、热稳定和金属络合性能。这些化合物具有低挥发性，特别适用于在高温下加工的工程树脂的紫外线稳定剂。
• Modulators of PPAR and methods of their preparation
  申请人：Zhu Yan

  公开号：US20060058301A1

  公开（公告）日：2006-03-16

  The present invention is directed to certain novel compounds represented by Formula (I) and pharmaceutically acceptable salts, solvates, hydrates and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulinemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity and eating disorders.

  本发明涉及由式（I）表示的某些新型化合物及其药学上可接受的盐、溶剂化合物、水合物和前药。本发明还涉及制备和使用这种化合物的方法，以及含有这种化合物的药物组合物，用于治疗或控制由PPAR介导的多种疾病，如葡萄糖代谢、脂质代谢和胰岛素分泌，特别是2型糖尿病、高胰岛素血症、高脂血症、高尿酸血症、高胆固醇血症、动脉粥样硬化、一种或多种心血管疾病风险因素、X综合症、高三酰甘油血症、高血糖症、肥胖症和进食障碍。
• MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION
  申请人：ZHU Yan

  公开号：US20100087468A1

  公开（公告）日：2010-04-08

  The present invention is directed to certain novel compounds represented by Formula (I) and pharmaceutically acceptable salts, solvates, hydrates and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulinemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity and eating disorders.

  本发明涉及一些新型化合物，其由公式（I）表示，以及其药学上可接受的盐、溶剂、水合物和前药。本发明还涉及制备和使用这些化合物的方法，以及含有这些化合物的药物组合物，用于治疗或控制由PPAR介导的许多疾病，例如葡萄糖代谢、脂质代谢和胰岛素分泌，具体包括2型糖尿病、高胰岛素血症、高脂血症、高尿酸血症、高胆固醇血症、动脉粥样硬化、一种或多种心血管疾病的风险因素、X综合症、高三酰甘油血症、高血糖、肥胖和进食障碍。
• Polyphenylene ether resin composition
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：EP0099231B1

  公开（公告）日：1987-11-25
• Liquid substituted 2H-benzotriazole mixtures
  申请人：CIBA-GEIGY AG

  公开号：EP0337942B1

  公开（公告）日：1994-07-06