1-(4-methoxyphenyl)-1-(2-phenylethynylbenzyl)silacyclobutane | 1335224-85-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(4-methoxyphenyl)-1-(2-phenylethynylbenzyl)silacyclobutane
• 英文别名: 1-(4-Methoxyphenyl)-1-[[2-(2-phenylethynyl)phenyl]methyl]siletane；1-(4-methoxyphenyl)-1-[[2-(2-phenylethynyl)phenyl]methyl]siletane
• CAS: 1335224-85-5
• 化学式: C₂₅H₂₄OSi
• 分子量: 368.55
• InChiKey: CNSUQGKYAFFHGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.94
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(4-methoxyphenyl)-1-(2-phenylethynylbenzyl)silacyclobutane 在 硼烷四氢呋喃络合物 、 allyl(cyclopentadiene)palladium(II) 、 10,16-dimethyl-N,N-bis[(1S)-1-phenylethyl]-12,14-dioxa-13-phosphapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3(8),9,16,18(23)-hexaen-13-amine 、 magnesium sulfate 作用下， 以 四氢呋喃 、 乙醚 、 甲苯 为溶剂， 反应 39.5h， 生成
  参考文献：
  名称：

  Palladium-Catalyzed Enantioselective Desymmetrization of Silacyclobutanes: Construction of Silacycles Possessing a Tetraorganosilicon Stereocenter

  摘要：

  A palladium-catalyzed desymmetrization of alkyne-tethered silacyclobutanes to give silacycles possessing a tetraorganosilicon stereocenter has been developed, and high chemo- and enantioselectivities have been achieved by the use of a newly synthesized chiral phosphoramidite ligand.

  DOI：

  10.1021/ja208621x
• 作为产物：
  描述：

  4-甲氧基苯基溴化镁 以 四氢呋喃 、 乙醚 为溶剂， 生成 1-(4-methoxyphenyl)-1-(2-phenylethynylbenzyl)silacyclobutane
  参考文献：
  名称：

  Palladium-Catalyzed Enantioselective Desymmetrization of Silacyclobutanes: Construction of Silacycles Possessing a Tetraorganosilicon Stereocenter

  摘要：

  A palladium-catalyzed desymmetrization of alkyne-tethered silacyclobutanes to give silacycles possessing a tetraorganosilicon stereocenter has been developed, and high chemo- and enantioselectivities have been achieved by the use of a newly synthesized chiral phosphoramidite ligand.

  DOI：

  10.1021/ja208621x

文献信息

• Palladium-Catalyzed Enantioselective Desymmetrization of Silacyclobutanes: Construction of Silacycles Possessing a Tetraorganosilicon Stereocenter
  作者：Ryo Shintani、Kohei Moriya、Tamio Hayashi

  DOI：10.1021/ja208621x

  日期：2011.10.19

  A palladium-catalyzed desymmetrization of alkyne-tethered silacyclobutanes to give silacycles possessing a tetraorganosilicon stereocenter has been developed, and high chemo- and enantioselectivities have been achieved by the use of a newly synthesized chiral phosphoramidite ligand.