4-hydroxy-6-methyl-3-propionylpyridin-2(1H)-one | 7135-82-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-hydroxy-6-methyl-3-propionylpyridin-2(1H)-one
• 英文别名: 3-Propionyl-4-hydroxy-6-methyl-2-pyridon；4-hydroxy-6-methyl-3-propionyl-1H-pyridin-2-one；2(1H)-Pyridone, 4-hydroxy-6-methyl-3-propionyl-；4-hydroxy-6-methyl-3-propanoyl-1H-pyridin-2-one
• CAS: 7135-82-2
• 化学式: C₉H₁₁NO₃
• 分子量: 181.191
• InChiKey: XJWVHLCIZXERQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-hydroxy-6-methyl-3-propionylpyridin-2(1H)-one 在 盐酸羟胺 、 碳酸氢钠 作用下， 以 乙醇 、 水 为溶剂， 反应 4.0h， 以65%的产率得到4-hydroxy-3-[(1E)-N-hydroxypropaneimidoyl]-6-methylpyridin-2(1H)-one
  参考文献：
  名称：

  Synthesis of Functionalized Pyrano[3,2‐c]pyridines and Their Transformations to 4‐Hydroxy‐3[(1E)‐N‐hydroxyalkanimidoyl]pyridones

  摘要：

  Reaction of 4-hydroxy-6-methyl-2(1H)-pyridones 1a and 4-hydroxy-1,6-dimethyl-2(1H)-pyridones 1b with diethyl malonates 2a-e leads to the formation of pyrano[3,2-c]pyridines 4a-j. Degradation of 4a-i affords the corresponding ketones 6a-i. Condensation of ketones 6a-i with hydroxyl amine or phenyl hydrazine hydrochloride is described.

  DOI：

  10.1080/00397910701547995
• 作为产物：
  描述：

  4-hydroxy-3,7-dimethyl-6H-pyrano[3,2-c]pyridine-2,5-dione 在 sodium hydroxide 作用下， 以 水 、 乙二醇 为溶剂， 反应 2.0h， 以70%的产率得到4-hydroxy-6-methyl-3-propionylpyridin-2(1H)-one
  参考文献：
  名称：

  Synthesis of Functionalized Pyrano[3,2‐c]pyridines and Their Transformations to 4‐Hydroxy‐3[(1E)‐N‐hydroxyalkanimidoyl]pyridones

  摘要：

  Reaction of 4-hydroxy-6-methyl-2(1H)-pyridones 1a and 4-hydroxy-1,6-dimethyl-2(1H)-pyridones 1b with diethyl malonates 2a-e leads to the formation of pyrano[3,2-c]pyridines 4a-j. Degradation of 4a-i affords the corresponding ketones 6a-i. Condensation of ketones 6a-i with hydroxyl amine or phenyl hydrazine hydrochloride is described.

  DOI：

  10.1080/00397910701547995

文献信息

• Synthesis of Functionalized Pyrano[3,2‐<i>c</i>]pyridines and Their Transformations to 4‐Hydroxy‐3[(1<i>E</i>)‐<i>N</i>‐hydroxyalkanimidoyl]pyridones
  作者：Farag A. El‐Essawy、Ahmed F. Khattab、Magdy A. Zahran、Sherif H. Gomaa

  DOI：10.1080/00397910701547995

  日期：2007.9.1

  Reaction of 4-hydroxy-6-methyl-2(1H)-pyridones 1a and 4-hydroxy-1,6-dimethyl-2(1H)-pyridones 1b with diethyl malonates 2a-e leads to the formation of pyrano[3,2-c]pyridines 4a-j. Degradation of 4a-i affords the corresponding ketones 6a-i. Condensation of ketones 6a-i with hydroxyl amine or phenyl hydrazine hydrochloride is described.