1-methyl-2-phenyl-1H-imidazole-4-methanol | 99280-78-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-methyl-2-phenyl-1H-imidazole-4-methanol
• 英文别名: (1-methyl-2-phenyl-1H-imidazol-4-yl)methanol；methyl-2-phenyl-4-imidazolemethanol；(1-methyl-2-phenylimidazol-4-yl)methanol
• CAS: 99280-78-1
• 化学式: C₁₁H₁₂N₂O
• 分子量: 188.229
• InChiKey: XOWFFOBIEGIMNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  38
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-methyl-2-phenyl-1H-imidazole-4-methanol 在 manganese(IV) oxide 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 以71%的产率得到1-甲基-2-苯基咪唑-4-甲醛
  参考文献：
  名称：

  强心剂。3.新型6-（取代的1H-咪唑-4（5）-基）-3（2H）-哒嗪酮的合成和生物学活性。

  摘要：

  几个6-（取代的1H-咪唑-4（5）-基）-3（2H）-哒嗪酮被合成并评估其正性肌力活性。1H-咪唑-4-基区域异构体4,5-二氢-6-（1-甲基-2-苯基-1H-咪唑-4-基）-3（2H）-哒嗪酮（25a）和6-（1-甲基-2-苯基-1H-咪唑-4-基）-3（2H）-哒嗪酮（28a）是有效的正性肌力药。相比之下，相应的1H-咪唑-5-基区域异构体25b和​​28b只是弱的正性肌力药。化合物25a和28a也是心脏磷酸二酯酶部分III的有效抑制剂。

  DOI：

  10.1021/jm00152a015
• 作为产物：
  描述：

  4-(((tert-butyldiphenylsilyl)oxy)methyl)-1-methyl-2-phenyl-1H-imidazole 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以47%的产率得到1-methyl-2-phenyl-1H-imidazole-4-methanol
  参考文献：
  名称：

  COMPOUNDS AND METHODS for the inhibition of HDAC

  摘要：

  公开号：

  EP2533783B1

文献信息

• [EN] PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF<br/>[FR] COMPOSÉS CONTENANT DE LA PIPÉRIDINE ET LEURS UTILISATIONS
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2010080864A1

  公开（公告）日：2010-07-15

  A method for preventing and/or treating a metabolic disease, cerebrovascular disease, etc. which comprises administering to a mammal an effective amount of the compound of the formula (I) wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. And a novel compound of the formula (I-1): wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof has an anti-diabetic effect and a neuroprotective effect. Accordingly, the compound of the formula (I) and the compound of the formula (I-1) are useful in a method for preventing and/or treating for a metabolic disease such as diabetes, cerebrovascular disease such as stroke, etc.

  一种预防和/或治疗代谢性疾病、脑血管疾病等的方法，包括向哺乳动物施用化合物的有效量，其化学式为(I)，其中所有符号的含义与规范中定义的相同；其盐、N-氧化物、溶剂合物或前药。以及化学式(I-1)的新化合物：其中所有符号的含义与规范中定义的相同；其盐、N-氧化物、溶剂合物或前药具有抗糖尿病作用和神经保护作用。因此，化合物(I)和化合物(I-1)在预防和/或治疗代谢性疾病如糖尿病、脑血管疾病如中风等方面是有用的。
• Curing resin composition and sealants and end-sealing materials for displays
  申请人：Watanabe Takashi

  公开号：US20070021524A1

  公开（公告）日：2007-01-25

  It is an object of the invention to provide a curing resin composition that scarcely causes pollution of a liquid crystal owing to elution of its components to the liquid crystal material and therefore, causes little unevenness of color in liquid crystal display in the case of using it as a sealant for a liquid crystal display element or an end-sealing material for a liquid crystal display element in fabrication of a liquid crystal display element and that is excellent in the storage stability and therefore, optimum for fabrication of a display apparatus especially by one drop fill process and to provide a sealant for a display element and an end-sealing material for a display element using the composition. The invention provides a curing resin composition to be used for a sealant or an end-sealing material for a display element, which comprises a curing resin together with a photopolymerization initiator and/or a curing agent and, has a carbonyl group derived from a (meth)acryl group together with an epoxy group and/or a hydroxyl group derived from an epoxy group and, a cured product of which has nitrogen atoms at a ratio of 3 to 10% by atom in the total of carbon atoms, hydrogen atoms and nitrogen atoms in the composition; a volume resistance of 1×10 13 Ω·cm or higher; a dielectric constant of 3 or higher at 100 kHz; and a glass transition temperature of 80 to 150° C.

  本发明的目的是提供一种固化树脂组合物，该组合物由于其成分向液晶材料渗出而几乎不会污染液晶，因此在将其用作液晶显示元件的密封剂或液晶显示元件的端部密封材料时，液晶显示中很少出现颜色不均匀，并且在储存稳定性方面表现出色优异，因此特别适用于通过一滴填充工艺制造显示装置，并提供使用该组合物的显示元件的密封剂和端部密封材料。本发明提供了一种用于显示元件的密封剂或端部密封材料的固化树脂组合物，该组合物包括固化树脂、光聚合引发剂和/或固化剂，具有由（甲基）丙烯酰基派生的羰基基团以及由环氧基派生的环氧基和/或羟基基团，其固化产物在碳原子、氢原子和氮原子的总和中的氮原子比例为3至10％的原子；体积电阻率为1×1013Ω·cm或更高；在100 kHz时具有3或更高的介电常数；和玻璃化转变温度为80至150℃。
• PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF
  申请人：Rodriguez Martha E.

  公开号：US20110275608A1

  公开（公告）日：2011-11-10

  A method for preventing and/or treating a metabolic disease, cerebrovascular disease, etc. which comprises administering to a mammal an effective amount of the compound of the formula (I): wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. And a novel compound of the formula (I-1): wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof has an anti-diabetic effect and a neuroprotective effect. Accordingly, the compound of the formula (I) and the compound of the formula (I-1) are useful in a method for preventing and/or treating for a metabolic disease such as diabetes, cerebrovascular disease such as stroke, etc.

  一种预防和/或治疗代谢性疾病、脑血管疾病等的方法，包括向哺乳动物投与公式(I)化合物的有效量：其中所有符号的含义与规范中定义的相同；其盐、N-氧化物、溶剂化物或前药。公式(I-1)的新化合物：其中所有符号的含义与规范中定义的相同；其盐、N-氧化物、溶剂化物或前药具有抗糖尿病和神经保护作用。因此，公式(I)和公式(I-1)的化合物在预防和/或治疗代谢性疾病（如糖尿病）、脑血管疾病（如中风）等方面有用。
• COMPOUNDS AND METHODS
  申请人：Baloglu Erkan

  公开号：US20130059883A1

  公开（公告）日：2013-03-07

  Disclosed are compounds having the formula: wherein X 1 , X 2 , X 3 , R 1 , R 2 , R 3 , R 4 , Y, A, Z, L and n are as defined herein, and methods of making and using the same.

  公开的化合物具有以下公式：其中X1，X2，X3，R1，R2，R3，R4，Y，A，Z，L和n的定义如下，以及制备和使用它们的方法。
• Compounds and methods
  申请人：Baloglu Erkan

  公开号：US08901156B2

  公开（公告）日：2014-12-02

  Disclosed are compounds having the formula: wherein X1, X2, X3, R1, R2, R3, R4, Y, A, Z, L and n are as defined herein, and methods of making and using the same.

  本文披露了具有以下式子的化合物： 其中X1、X2、X3、R1、R2、R3、R4、Y、A、Z、L和n的定义如本文所述，并且还披露了制备和使用这些化合物的方法。