2-(4-chlorophenyl)-6-methoxyimidazo<1,2-b>pyridazine | 1844-64-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-chlorophenyl)-6-methoxyimidazo<1,2-b>pyridazine
• 英文别名: 6-Methoxy-2-(4-chlorphenyl)imidazo<1,2-b>pyridazin；2-(4-chloro-phenyl)-6-methoxy-imidazo[1,2-b]pyridazine；Imidazo[1,2-b]pyridazine,2-(4-chlorophenyl)-6-methoxy-；2-(4-chlorophenyl)-6-methoxyimidazo[1,2-b]pyridazine
• CAS: 1844-64-0
• 化学式: C₁₃H₁₀ClN₃O
• 分子量: 259.695
• InChiKey: MUHOBOJQYDCNIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  39.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-羟甲基苯甲酰胺 、 2-(4-chlorophenyl)-6-methoxyimidazo<1,2-b>pyridazine 在 硫酸 、 溶剂黄146 作用下， 反应 24.0h， 以30%的产率得到N-[2-(4-Chloro-phenyl)-6-methoxy-imidazo[1,2-b]pyridazin-3-ylmethyl]-benzamide
  参考文献：
  名称：

  Syntheses, pharmacological evaluation and molecular modelling of substituted 6-alkoxyimidazo[1,2-b]pyridazines as new ligands for the benzodiazepine receptor

  摘要：

  A series of 2,3-disubstituted-6-alkoxyimidazo[1,2-b] has been synthesized and evaluated for in vitro affinity for the benzodiazepine receptor (BZR). 3-(Benzamidomethyl or substituted benzamidomethyl)-6-methoxy-2-(3,4-methylenedioxyphenyl)imidazo[1,2-b]pyridazines were found to be the most potent BZR ligands (eg, 4a, IC50 7 nM; 4e, IC50 14 nM; 4v, IC50 8 nM). Imidazo[1,2-b]pyridazines unsubstituted in the 3-position, or containing builder alkoxy groups in the 6-position, were found to bind less strongly to the BZR. Selected compounds from the series were identified from in vitro GABA-shift experiments as BZR agonists. Molecular modelling has been employed to identify the common pharmacophoric points of lipophilic and hydrogen bonding, ligand-receptor interaction and areas of steric hindrance for these substituted imidazo[1,2-b]pyridazines at the BZR.

  DOI：

  10.1016/0223-5234(96)85873-9
• 作为产物：
  描述：

  3-氨基-6-甲氧基哒嗪 、 2'-溴-4-氯苯乙酮 在 碳酸氢钠 作用下， 生成 2-(4-chlorophenyl)-6-methoxyimidazo<1,2-b>pyridazine
  参考文献：
  名称：

  Syntheses, pharmacological evaluation and molecular modelling of substituted 6-alkoxyimidazo[1,2-b]pyridazines as new ligands for the benzodiazepine receptor

  摘要：

  A series of 2,3-disubstituted-6-alkoxyimidazo[1,2-b] has been synthesized and evaluated for in vitro affinity for the benzodiazepine receptor (BZR). 3-(Benzamidomethyl or substituted benzamidomethyl)-6-methoxy-2-(3,4-methylenedioxyphenyl)imidazo[1,2-b]pyridazines were found to be the most potent BZR ligands (eg, 4a, IC50 7 nM; 4e, IC50 14 nM; 4v, IC50 8 nM). Imidazo[1,2-b]pyridazines unsubstituted in the 3-position, or containing builder alkoxy groups in the 6-position, were found to bind less strongly to the BZR. Selected compounds from the series were identified from in vitro GABA-shift experiments as BZR agonists. Molecular modelling has been employed to identify the common pharmacophoric points of lipophilic and hydrogen bonding, ligand-receptor interaction and areas of steric hindrance for these substituted imidazo[1,2-b]pyridazines at the BZR.

  DOI：

  10.1016/0223-5234(96)85873-9