2-[(4-Chlorophenyl)sulfanyl]-4-(4-methylphenyl)-4-oxobutanoic acid | 298217-66-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[(4-Chlorophenyl)sulfanyl]-4-(4-methylphenyl)-4-oxobutanoic acid
• 英文别名: 2-(4-chlorophenyl)sulfanyl-4-(4-methylphenyl)-4-oxobutanoic acid
• CAS: 298217-66-0
• 化学式: C₁₇H₁₅ClO₃S
• 分子量: 334.8
• InChiKey: CYRWMDIDRVATIQ-UHFFFAOYSA-N

物化性质

• 沸点：
  528.3±50.0 °C(Predicted)
• 密度：
  1.34±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  79.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• TOPICAL LIGHTENING COMPOSITION AND USES THEREOF
  申请人：Avon Products, Inc.

  公开号：EP2521558A1

  公开（公告）日：2012-11-14
• Topical Lightening Composition and Uses Thereof
  申请人：Lyga John W.

  公开号：US20120003168A1

  公开（公告）日：2012-01-05

  The disclosure relates to novel topical lightening compositions a skin depigmenting agent and a vehicle. There is provided a topical lightening composition comprising a substituted-4-oxobutanoic acid, ester, or amide tyrosinase inhibitor, and a vehicle. The depigmenting agents of this disclosure can be used as such or as a pharmaceutically acceptable salt including conventional non-toxic salts which include a metal salt or an alkaline earth metal salt, an ammonium salt, or an organic base salt. The depigmenting agents of this disclosure can be incorporated into any cosmetically-, dermatologically-, or cosmeticatically-acceptable vehicle or carrier normally used for topical application. The compositions and methods of the disclosure are effective to lighten skin, hair, lips, and/or nails.
• US8329149B2
  申请人：——

  公开号：US8329149B2

  公开（公告）日：2012-12-11
• [EN] TOPICAL LIGHTENING COMPOSITION AND USES THEREOF<br/>[FR] COMPOSITION ÉCLAIRCISSANTE TOPIQUE ET UTILISATIONS DE CELLE-CI
  申请人：AVON PROD INC

  公开号：WO2011082044A1

  公开（公告）日：2011-07-07

  The disclosure relates to novel topical lightening compositions a tyrosinase inhibitor and a vehicle. There is provided a topical lightening composition comprising a 2-substituted-thio-4-substitued-4-oxobutanoic acid, ester or amide tyrosinase inhibitor, and a vehicle. The tyrosinase inhibitors of this disclosure can be used as such or as a pharmaceutically acceptable salt including conventional non-toxic salts which include a metal salt or an alkaline earth metal salt, an ammonium salt, or an organic base salt. The tyrosinase inhibitors of this disclosure can be incorporated into any cosmetically-, dermatologically-, or cosmeticatically- acceptable vehicle or carrier normally used for topical application. The compositions and methods of the disclosure are effective to lighten skin, hair, lips, and/or nails.