2-[(naphthalen-1-yl)methylene]-1-(2-methyl-8-methoxyquinolin-4-yl)hydrazine | 1189345-01-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-[(naphthalen-1-yl)methylene]-1-(2-methyl-8-methoxyquinolin-4-yl)hydrazine
• 英文别名: 8-methoxy-2-methyl-N-(naphthalen-1-ylmethylideneamino)quinolin-4-amine
• CAS: 1189345-01-4
• 化学式: C₂₂H₁₉N₃O
• 分子量: 341.412
• InChiKey: LAYNXCHJELKMOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.15
• 重原子数：
  26.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  46.51
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  1-萘甲醛 、 4-肼基-8-甲氧基-2-甲基喹啉 以 乙醇 为溶剂， 生成 2-[(naphthalen-1-yl)methylene]-1-(2-methyl-8-methoxyquinolin-4-yl)hydrazine
  参考文献：
  名称：

  Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure–activity relationship studies

  摘要：

  A series of 4-quinolylhydrazones was synthesized and tested in vitro against Mycobacterium tuberculosis. At a concentration of 6.25 mu g/mL, most of the newly synthesized compounds displayed 100% inhibitory activity against M. tuberculosis in cellular assays. Further screening allowed the identification of very potent antitubercular agents. Compound 4c was also tested in a time-course experiment and against mtb clinical isolates, displaying interesting results. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.06.051

文献信息

• Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure–activity relationship studies
  作者：Sandra Gemma、Luisa Savini、Maria Altarelli、Pierangela Tripaldi、Luisa Chiasserini、Salvatore Sanna Coccone、Vinod Kumar、Caterina Camodeca、Giuseppe Campiani、Ettore Novellino、Sandra Clarizio、Giovanni Delogu、Stefania Butini

  DOI：10.1016/j.bmc.2009.06.051

  日期：2009.8

  A series of 4-quinolylhydrazones was synthesized and tested in vitro against Mycobacterium tuberculosis. At a concentration of 6.25 mu g/mL, most of the newly synthesized compounds displayed 100% inhibitory activity against M. tuberculosis in cellular assays. Further screening allowed the identification of very potent antitubercular agents. Compound 4c was also tested in a time-course experiment and against mtb clinical isolates, displaying interesting results. (C) 2009 Elsevier Ltd. All rights reserved.