2-indanebutyric amide | 166183-37-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 2-indanebutyric amide
• 英文别名: 4-(2,3-dihydro-1H-inden-2-yl)butanamide
• CAS: 166183-37-5
• 化学式: C₁₃H₁₇NO
• 分子量: 203.284
• InChiKey: HJUVNYMKCGDBGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-indanebutyric amide 在 lithium aluminium tetrahydride 、 三氯化铝 、 potassium carbonate 作用下， 生成 N-[4-(5-Acetyl-indan-2-yl)-butyl]-4-chloro-benzenesulfonamide
  参考文献：
  名称：

  Synthesis and thromboxane A2 antagonistic activity of indane derivatives

  摘要：

  A new series of indane derivatives were prepared and evaluated for their thromboxane A(2) (TXA(2), 1) antagonistic activity. Among these compounds, 24a (Z-335) was found to be a potent TXA(2) antagonist in oral administration. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00014-1
• 作为产物：
  描述：

  benzyl 4-(indan-2-yl)-2-butenoate 在 钯 氯化亚砜 、 氢气 、 氯化铵 作用下， 生成 2-indanebutyric amide
  参考文献：
  名称：

  Synthesis and thromboxane A2 antagonistic activity of indane derivatives

  摘要：

  A new series of indane derivatives were prepared and evaluated for their thromboxane A(2) (TXA(2), 1) antagonistic activity. Among these compounds, 24a (Z-335) was found to be a potent TXA(2) antagonist in oral administration. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00014-1

文献信息

• Indane derivative and processes for preparing the same
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP0661273A1

  公开（公告）日：1995-07-05

  Disclosed are an indane compound represented by the formula:    wherein R¹ represents a lower alkyl group, a lower alkenyl group or a substituted or unsubstituted monocyclic aromatic heterocyclic group having nitrogen atom as a hetero atom; R² represents hydrogen atom or a lower alkyl group; and A represents a lower alkylene group, or a pharmaceutically acceptable salt thereof and processes for preparing the same.

  本发明公开了一种由式表示的茚满化合物： 其中，R¹代表低级烷基、低级烯基或取代或未取代的单环芳香杂环基团，其氮原子为杂原子；R²代表氢原子或低级烷基；A代表低级亚烷基、 或其药学上可接受的盐及其制备工艺。
• Indane derivatives and processes for preparing the same
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP0661273B1

  公开（公告）日：1999-05-19
• US5686452A
  申请人：——

  公开号：US5686452A

  公开（公告）日：1997-11-11
• Synthesis and thromboxane A2 antagonistic activity of indane derivatives
  作者：Katsuo Shinozaki、Hiroki Sato、Takeo Iwakuma、Ryuichi Sato、Tadashi Kurimoto、Kiyoshi Yoshida

  DOI：10.1016/s0960-894x(99)00014-1

  日期：1999.2

  A new series of indane derivatives were prepared and evaluated for their thromboxane A(2) (TXA(2), 1) antagonistic activity. Among these compounds, 24a (Z-335) was found to be a potent TXA(2) antagonist in oral administration. (C) 1999 Elsevier Science Ltd. All rights reserved.