[[(2S,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3-azido-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: [[(2S,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3-azido-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate
• 英文别名: [[(2S,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3-azidooxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• 化学式: C10H15N8O12P3
• 分子量: 532.19
• InChiKey: JZBFFCANYXZLES-KVQBGUIXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  273
• 氢给体数：
  6
• 氢受体数：
  18

文献信息

• RNA CAPPING METHOD, PRODUCTION METHOD FOR MODIFIED RNA, AND MODIFIED RNA
  申请人：Kyoto University

  公开号：EP3950699A1

  公开（公告）日：2022-02-09

  An RNA capping method including a step of reacting a compound (1) represented by the following general formula (1) with an RNA in the presence of a Vaccinia virus capping enzyme (Rb1 represents an oxo group, an alkoxy group, or a halogen atom; Rb2 is either absent or represents an alkyl group; Rb3 represents an amino group or a hydrogen atom; Rb4 is either absent or represents a hydrogen atom or an alkyl group; Rr1 represents a hydroxy group, an alkoxy group having 1 to 3 carbon atoms, an amino group, an azide group, -OR1C≡CH, or -R2R3; Rr2 represents a hydrogen atom, a hydroxy group, a halogen atom, an alkoxy group, an amino group, an azide group, - OR1C≡CH, or -R2R3; and A1 represents an oxygen atom or a sulfur atom).

  一种RNA封端方法，包括以下通式(1)代表的化合物(1)与RNA在Vaccinia病毒封端酶存在下反应的步骤 (Rb1代表氧代基团、烷氧基或卤原子；Rb2要么不存在，要么代表烷基；Rb3代表氨基或氢原子；Rr1 代表羟基、具有 1 至 3 个碳原子的烷氧基、氨基、叠氮基、-OR1C≡CH 或 -R2R3；Rr2 代表氢原子、羟基、卤素原子、烷氧基、氨基、叠氮基、-OR1C≡CH 或 -R2R3；A1 代表氧原子或硫原子）。
• KITS AND METHODS FOR GENERATING 5' CAPPED RNA
  申请人：Epicentre Technologies

  公开号：EP2010659A2

  公开（公告）日：2009-01-07
• Kits and methods for generating 5' capped RNA
  申请人：CellScript, Inc.

  公开号：EP2010659B1

  公开（公告）日：2014-06-18
• US8846348B2
  申请人：——

  公开号：US8846348B2

  公开（公告）日：2014-09-30
• US9005930B2
  申请人：——

  公开号：US9005930B2

  公开（公告）日：2015-04-14