1-(2'-picolyl)-5-isopropyl-6-(3',5'-dimethylbenzoyl)-2,4-pyrimidinedione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2'-picolyl)-5-isopropyl-6-(3',5'-dimethylbenzoyl)-2,4-pyrimidinedione
• 英文别名: 6-(3,5-Dimethylbenzoyl)-5-isopropyl-1-(2-pyridylmethyl)pyrimidine-2,4-dione；6-(3,5-dimethylbenzoyl)-5-propan-2-yl-1-(pyridin-2-ylmethyl)pyrimidine-2,4-dione
• 化学式: C₂₂H₂₃N₃O₃
• 分子量: 377.443
• InChiKey: VLFMRFPTZLCGRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  79.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] ANTIVIRAL PYRIMIDINEDIONE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF<br/>[FR] DERIVES DE PYRIMIDINEDIONE, A PROPRIETE ANTIVIRALE, ET PROCEDE DE PREPARATION ASSOCIE
  申请人：SAMJIN PHARM CO LTD

  公开号：WO2000061564A1

  公开（公告）日：2000-10-19

  The present invention relates to pyrimidinedione derivatives of following formula (I) which are useful as antiviral agents, especially as agents for treatment of AIDS, pharmaceutically acceptable salts thereof, process for the preparation thereof and pharmaceutical compositions containing the same, wherein R represents cyclopropyl; cyclobutyl; cyclohexyl; unsubstituted or mono-, di- or tri-substituted phenyl with a group selected from hydroxy, C1-C4 alkyl, C1-C4 alkoxy, halogen, trifluoromethyl, cyano and amino; 1- or 2-naphthyl; 9-anthracenyl; 2-anthraquinonyl; unsubstituted or substituted pyridyl with a group selected from C1-C4 alkyl, C1-C4 alkoxy, cyano and halogen; 2-, 3- or 4-quinolinyl; oxiranyl; 1-benzotriazolyl; 2-benzoxazolyl; furanyl substituted with C1-C4 alkoxycarbonyl; C1-C4 alkylcarbonyl; or benzoyl, R1 represents halogen or C1-C4 alkyl, R2 and R3 represent independently hydrogen or C1-C4 alkyl, X represents oxygen atom, and Y represents oxygen atom, sulfur atom or carbonyl.

  本发明涉及以下式（I）的嘧啶二酮衍生物，其可用作抗病毒剂，尤其是用于治疗艾滋病的药物，其药学上可接受的盐，其制备方法以及包含其的制药组合物，其中R代表环丙基；环丁基；环己基；未取代或取代的苯基，所述苯基带有从羟基，C1-C4烷基，C1-C4烷氧基，卤素，三氟甲基，氰基和氨基中选择的基团; 1-或2-萘基；9-蒽基；2-蒽醌基；未取代或取代的吡啶基，所述吡啶基带有从C1-C4烷基，C1-C4烷氧基，氰基和卤素中选择的基团；2-，3-或4-喹啉基；环氧乙基基；1-苯并三氮唑基；2-苯并噁唑基；被C1-C4烷氧羰基，C1-C4烷基羰基或苯甲酰基取代的呋喃基，R1代表卤素或C1-C4烷基，R2和R3独立地代表氢或C1-C4烷基，X代表氧原子，Y代表氧原子，硫原子或羰基。
• ANTIVIRAL PYRIMIDINEDIONE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF
  申请人：Samjin Pharmaceutical Co., Ltd.

  公开号：EP1100786A1

  公开（公告）日：2001-05-23
• ANTIVIRAL 2,4-PYRIMIDINEDIONE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF
  申请人：Korea Research Institute of Chemical Technology

  公开号：EP1159271B1

  公开（公告）日：2004-08-25