Demethylmacrocin

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Demethylmacrocin
• 英文别名: 2-[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-5,9,13-trimethyl-2,10-dioxo-15-[[(2R,3R,4R,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde
• 化学式: C₄₄H₇₃NO₁₇
• 分子量: 888.0
• InChiKey: ALZAOGATQMXJKX-UQRCBBHQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  62
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  261
• 氢给体数：
  7
• 氢受体数：
  18

文献信息

• C-20- and C-23-modified macrolide derivatives
  申请人：ELI LILLY AND COMPANY

  公开号：EP0124216A1

  公开（公告）日：1984-11-07

  Tylosin-like macrolides modified at C-20 and C-23.

  C-20和C-23修饰的泰乐菌素类大环内酯。
• Method for producing 2'''-0-demethyltylosin
  申请人：ELI LILLY AND COMPANY

  公开号：EP0335573A2

  公开（公告）日：1989-10-04

  The present invention discloses a method for producing 2‴-O-demethyltylosin, which comprises culturing a tylosin producing strain of Streptomyces, said strain: a) comprising one or more mutations that prevent the expression of tylosin biosynthetic gene tylE; and b) being transformed with a recombinant DNA cloning vector which comprises DNA which codes for the expression of tylosin biosynthetic gene tylF; said culture conditions suitable for cell growth, expression of the tylF gene, and production of 2‴-­O-demethyltylosin.

  本发明公开了一种生产 2‴-O-去甲基酪脂素的方法，该方法包括培养产生泰乐菌素的链霉菌株，所述菌株： a) 包含一个或多个突变，阻止泰乐菌素生物合成基因 tylE 的表达；以及 b) 被重组 DNA 克隆载体转化，该载体包含编码表达泰乐菌素生物合成基因 tylF 的 DNA； 所述培养条件适合细胞生长、表达 tylF 基因和生产 2‴-O-去甲基tylosin。
• Novel use of the site-specific integrating function of phage OC31
  申请人：ELI LILLY AND COMPANY

  公开号：EP0403173A2

  公开（公告）日：1990-12-19

  The present invention provides a method for transforming an actinomycete with an integrating vector which has the advantages of high transformation rates into a broad host range, site-specific integration, and stable maintenance without antibiotic selection. Also provided are methods for the increased production of antibiotics and for the production of hybrid anti­biotics.

  本发明提供了一种用整合载体转化放线菌的方法，该方法具有转化率高、宿主范围广、整合位点特异、无需抗生素选择即可稳定维持等优点。本发明还提供了提高抗生素产量和生产混合抗生素的方法。
• Macrolide antibiotics, their preparation and veterinary compositions containing them
  申请人：ELI LILLY AND COMPANY

  公开号：EP0045157B1

  公开（公告）日：1984-04-18
• Improvements in or relating to tylosin antibiotic-producing microorganisms
  申请人：ELI LILLY AND COMPANY

  公开号：EP0238323B1

  公开（公告）日：1994-12-28