Alectrol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: Alectrol
• 英文别名: (3E,3aR,8bS)-8a-hydroxy-8,8-dimethyl-3-[[(2R)-4-methyl-5-oxo-2H-furan-2-yl]oxymethylidene]-5,6,7,8b-tetrahydro-3aH-indeno[1,2-b]furan-2-one
• 化学式: C₁₉H₂₂O₆
• 分子量: 346.4
• InChiKey: FIKOOQXJBAJJSE-YTQTXRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  82.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• COMPOSITION AND METHOD FOR INFLUENCING ENERGY METABOLISM AND TREATING METABOLIC AND OTHER DISORDERS
  申请人：Laakso Markku

  公开号：US20140142170A1

  公开（公告）日：2014-05-22

  A composition and method for influencing energy metabolism and treating metabolic and other disorders is provided. A terpenoid lactone that is a selective activator of SIRT1 is generally in the form of a terpenoid dilactone having a 5-alkeny-loxy-furan-2- one group, such as strigolactone, GR 24, or another strigolactone analog, and is used as a therapeutic agent in a method for influencing energy metabolism and treating metabolic and other disorders. The terpenoid lactone may be administered as an individual agent or combined with a second compound such as a flavonoid, chalconoid, tannin, or nicotinamide inhibition antagonist.

  提供了一种影响能量代谢和治疗代谢和其他疾病的组合物和方法。一种选择性激活SIRT1的萜类内酯通常以萜类二内酯的形式存在，其中包含5-烯氧基呋喃-2-酮基团，例如石竹内酯，GR 24或另一种石竹内酯类似物，并用作影响能量代谢和治疗代谢和其他疾病的方法中的治疗剂。萜类内酯可以作为单独的药剂或与第二化合物（如类黄酮，查尔酮，单宁或烟酰胺抑制剂）结合使用。
• Use of strigolactones and strigolactone analogs for treating proliferative conditions
  申请人：The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO)

  公开号：US10208007B2

  公开（公告）日：2019-02-19

  Compound of formula X wherein P1 is a fused-ring system comprising one 6-membered and two 5-membered rings; v indicates an S or R configuration; or individual isomers or pharmaceutically acceptable salts thereof, or mixtures thereof, in the preparation of an active agent for preventing or inhibiting cell proliferation or for inducing cell death.

  式 X 的化合物，其中 P1 是由一个 6 元环和两个 5 元环组成的融合环体系；v 表示 S 或 R 构型；或其单个异构体或药学上可接受的盐，或其混合物，用于制备防止或抑制细胞增殖或诱导细胞死亡的活性剂。
• USE OF STRIGOLACTONES AND STRIGOLACTONE ANALOGS FOR TREATING PROLIFERATIVE CONDITIONS
  申请人：Georgetown University

  公开号：US20140323563A1

  公开（公告）日：2014-10-30

  Compound of formula X wherein P 1 is a fused-ring system comprising one 6-membered and two 5-membered rings; v indicates an S or R configuration; or individual isomers or pharmaceutically acceptable salts thereof, or mixtures thereof, in the preparation of an active agent for preventing or inhibiting cell proliferation or for inducing cell death.