Harzianopyridone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Harzianopyridone
• 英文别名: 4-hydroxy-5,6-dimethoxy-3-[(E,2R)-2-methylhex-4-enoyl]-1H-pyridin-2-one
• 化学式: C₁₄H₁₉NO₅
• 分子量: 281.3
• InChiKey: FPYAYFJAGDIMEX-HQZHTGGTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  88.9
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Uses of Bcl-2 Antagonists for Treating Cancer and Diagnostics Related Thereto
  申请人：Emory University

  公开号：US20190328729A1

  公开（公告）日：2019-10-31

  In certain embodiments, this disclosure relates to method of treating and diagnosing cancer by administering a Bcl-2 inhibitor optionally in combination with a mitochondrial complex II inhibitor. In certain embodiments, a subject is diagnosed with, exhibiting symptoms of, or at risk of cancer wherein the cancer is a hematological malignancy such as multiple myeloma, leukemia, or lymphoma.