N-乙酰基氨基甘露醇醛酸 | 32452-11-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: N-乙酰基氨基甘露醇醛酸
• 英文名称: N-Acetyl-D-mannosaminuronic acid
• 英文别名: (2S,3S,4R,5S)-5-acetamido-2,3,4-trihydroxy-6-oxohexanoic acid
• CAS: 32452-11-2；57496-35-2
• 化学式: C₈H₁₃NO₇
• 分子量: 235.19
• InChiKey: MQWZJOSNNICZJE-JWXFUTCRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  144
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• Capsular gram-positive bacteria bioconjugate vaccines
  申请人：GLAXOSMITHKLINE BIOLOGICALS S.A.

  公开号：US10307473B2

  公开（公告）日：2019-06-04

  The present invention encompasses a novel S. aureus bioconjugate vaccine. More generally, the invention is directed to Gram-positive and other bioconjugate vaccines containing a protein carrier, at least one polysaccharide such as a capsular Gram-positive polysaccharide, and, optionally, an adjuvant or pharmaceutically acceptable carrier. The instant invention also includes methods of producing Gram-positive and other bioconjugate vaccines. An N-glycosylated protein is also provided that contains one or more polysaccharides such as Gram-positive polysaccharides. The invention is additionally directed to engineered prokaryotic organisms comprising nucleotide sequences encoding a glycosyltransferase of a first prokaryotic organism and a glycosyltransferase of a second prokaryotic organism. The invention further includes plasmids and prokaryotic cells transformed with plasmids encoding polysaccharides and enzymes which produce an N-glycosylated protein and/or bioconjugate vaccine. Further, the invention is directed to methods of inducing an immune response in a mammal comprising administering said bioconjugate vaccines.

  本发明包括一种新型金黄色葡萄球菌生物结合疫苗。更一般地说，本发明涉及革兰氏阳性菌和其他生物结合疫苗，其中含有蛋白质载体、至少一种多糖（如胶囊革兰氏阳性菌多糖）以及可选的佐剂或药学上可接受的载体。本发明还包括生产革兰氏阳性疫苗和其他生物结合疫苗的方法。本发明还提供了一种含有一种或多种多糖（如革兰氏阳性多糖）的 N-糖基化蛋白质。本发明还涉及工程原核生物，其包含编码第一种原核生物的糖基转移酶和第二种原核生物的糖基转移酶的核苷酸序列。本发明还包括质粒和用编码多糖和酶的质粒转化的原核细胞，这些质粒和酶可产生 N-糖基化蛋白质和/或生物结合疫苗。此外，本发明还涉及诱导哺乳动物免疫应答的方法，包括注射所述生物结合疫苗。
• POLYSACCHARIDE - STAPHYLOCOCCAL SURFACE ADHESIN CARRIER PROTEIN CONJUGATES FOR IMMUNIZATION AGAINST NOSOCOMIAL INFECTIONS
  申请人：Wyeth Holdings Corporation

  公开号：EP1601381A2

  公开（公告）日：2005-12-07
• IMMUNOGENIC COMPOSITIONS OF STAPHYLOCOCCUS AUREUS ANTIGENS
  申请人：Wyeth LLC

  公开号：EP2445522B1

  公开（公告）日：2017-08-09
• CAPSULAR GRAM-POSITIVE BACTERIA BIOCONJUGATE VACCINES
  申请人：Glycovaxyn AG

  公开号：EP2566507A1

  公开（公告）日：2013-03-13
• STABLE IMMUNOGENIC COMPOSITIONS OF STAPHYLOCOCCUS AUREUS ANTIGENS
  申请人：Wyeth LLC

  公开号：EP2654784A2

  公开（公告）日：2013-10-30