N-去丙基普罗帕酮 | 86383-21-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 中文名称: N-去丙基普罗帕酮
• 英文名称: N-Depropylpropafenone
• 英文别名: 1-[2-(3-amino-2-hydroxypropoxy)phenyl]-3-phenylpropan-1-one
• CAS: 86383-21-3
• 化学式: C₁₈H₂₁NO₃
• 分子量: 299.4
• InChiKey: HIGKMVIPYOFHBP-UHFFFAOYSA-N

物化性质

• 熔点：
  148-1500C
• 沸点：
  506.2±50.0 °C(Predicted)
• 密度：
  1.165±0.06 g/cm3(Predicted)
• 溶解度：
  甲醇（微溶）、水（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

ADMET

代谢

N-去丙基丙afenone是丙afenone的一个已知人体代谢物。

N-Despropylpropafenone is a known human metabolite of Propafenone.

来源:NORMAN Suspect List Exchange

文献信息

• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DE MALADIES CARDIOVASCULAIRES
  申请人：KANDULA MAHESH

  公开号：WO2014080306A2

  公开（公告）日：2014-05-30

  The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II; and methods for treating or preventing cardiovascular diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of coronary heart diseases, hypertension, heart failure, inflammatory bowel disease, Tachycardia, Flutter, atrial fibrillation, atrial flutter, arryhthimias, valvular heart disease, stroke, cerebrovascular disease, ventricular fibrillation, QT prolongation, peripheral arterial disease, kidney diseases, diabetes related renal complications, hypertension, albuminuria, ESRD, Kidney GFR complications, Vascular Disease and Ventricular Septal Defect.