5-amino-4-acetyl-1-phenyl-1,2,3-triazole | 129959-30-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-amino-4-acetyl-1-phenyl-1,2,3-triazole
• 英文别名: 1-[5-amino-1-phenyl-1H-1,2,3-triazole-4-yl]ethanone；1-(5-Amino-1-phenyltriazol-4-yl)ethanone
• CAS: 129959-30-4
• 化学式: C₁₀H₁₀N₄O
• 分子量: 202.216
• InChiKey: IGVHAWCALJTZLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  73.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-amino-4-acetyl-1-phenyl-1,2,3-triazole 在 ammonium acetate 作用下， 以 乙醇 、 苯 为溶剂， 反应 7.0h， 生成 7-methyl-3-phenyl-3H-1,2,3-triazolo<4,5-d>pyrimidine
  参考文献：
  名称：

  Synthesis of derivatives of 5-amino-4-acyl-1,2,3-triazole, 8-azapurine, and 1,2,3-triazolo[4,5-b]pyridin-7-one using N,N-acetals of acylketenes and tosylazide

  摘要：

  By reaction of N,N-acetals of acylketenes with tosylazide there were synthesized 5-amino-4-acyl-1,2,3-triazoles substituted at the endo(N1)- or exocyclic nitrogen atom. Triazoles containing a free NH2 group were used in the synthesis of the corresponding 8-azapurines and 4-acetyl-5-benzoylamino-1,2,3-triazole afforded 2-methyl-2H,4H-1,2,3-triazolo[4,5-b]pyridin-7-one.

  DOI：

  10.1007/bf00962394
• 作为产物：
  描述：

  (Z)-4-Amino-4-phenylamino-but-3-en-2-one 在 对甲苯磺酰叠氮 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以13%的产率得到4-acetyl-5-phenylamino-1,2,3-triazole
  参考文献：
  名称：

  Synthesis of derivatives of 5-amino-4-acyl-1,2,3-triazole, 8-azapurine, and 1,2,3-triazolo[4,5-b]pyridin-7-one using N,N-acetals of acylketenes and tosylazide

  摘要：

  By reaction of N,N-acetals of acylketenes with tosylazide there were synthesized 5-amino-4-acyl-1,2,3-triazoles substituted at the endo(N1)- or exocyclic nitrogen atom. Triazoles containing a free NH2 group were used in the synthesis of the corresponding 8-azapurines and 4-acetyl-5-benzoylamino-1,2,3-triazole afforded 2-methyl-2H,4H-1,2,3-triazolo[4,5-b]pyridin-7-one.

  DOI：

  10.1007/bf00962394

文献信息

• COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY
  申请人：Liu Hong

  公开号：US20120225869A1

  公开（公告）日：2012-09-06

  The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).

  本发明提供了化合物、包括这些化合物的药物组合物以及使用这些化合物来治疗或预防与大麻素受体1（CB1）的活性相关的疾病或障碍的方法。
• Consecutive Tandem Cycloaddition between Nitriles and Azides; Synthesis of 5-Amino-1H-[1,2,3]-triazoles
  作者：José Cavaleiro、Fernando da Silva、Ana Gomes、Priscila Martins、David Rocha、Maria Neves、Vitor Ferreira、Artur Silva

  DOI：10.1055/s-0032-1317712

  日期：——

  Novel 5-amino-1H-1,2,3-triazoles were synthesized by a new synthetic route that involves consecutive tandem cycloaddition between nitriles and azides.
• GORDEEV, M. F.;KOMKOV, A. V.;BOGDANOV, V. S.;DOROXOV, V. A., IZV. AN CCCP. CEP. XIM.,(1990) N, S. 1392-1397
  作者：GORDEEV, M. F.、KOMKOV, A. V.、BOGDANOV, V. S.、DOROXOV, V. A.

  DOI：——

  日期：——
• Synthesis of derivatives of 5-amino-4-acyl-1,2,3-triazole, 8-azapurine, and 1,2,3-triazolo[4,5-b]pyridin-7-one using N,N-acetals of acylketenes and tosylazide
  作者：M. F. Gordeev、A. V. Komkov、V. S. Bogdanov、V. A. Dorokhov

  DOI：10.1007/bf00962394

  日期：1990.6

  By reaction of N,N-acetals of acylketenes with tosylazide there were synthesized 5-amino-4-acyl-1,2,3-triazoles substituted at the endo(N1)- or exocyclic nitrogen atom. Triazoles containing a free NH2 group were used in the synthesis of the corresponding 8-azapurines and 4-acetyl-5-benzoylamino-1,2,3-triazole afforded 2-methyl-2H,4H-1,2,3-triazolo[4,5-b]pyridin-7-one.