(2E,4E)-N-hydroxy-9-oxo-9-(4-phenylphenyl)nona-2,4-dienamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2E,4E)-N-hydroxy-9-oxo-9-(4-phenylphenyl)nona-2,4-dienamide
• 化学式: C₂₁H₂₁NO₃
• 分子量: 335.4
• InChiKey: NRYMYNMTWFSJMV-YCCJYARSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• METHODS AND COMPOUNDS FOR PREVENTING AND TREATING A TUMOUR
  申请人：Agency for Science, Technology And Research

  公开号：EP2217240A1

  公开（公告）日：2010-08-18
• US8969313B2
  申请人：——

  公开号：US8969313B2

  公开（公告）日：2015-03-03
• [EN] METHODS AND COMPOUNDS FOR PREVENTING AND TREATING A TUMOUR<br/>[FR] MÉTHODES ET COMPOSÉS POUR LA PRÉVENTION ET LE TRAITEMENT D'UNE TUMEUR
  申请人：AGENCY SCIENCE TECH & RES

  公开号：WO2009058102A1

  公开（公告）日：2009-05-07

  The invention relates to a method of preventing, inhibiting, arresting or reversing tumourigenesis in a cell as well as a method of inducing apoptosis in a tumour cell. The method includes increasing the amount and/or the activity of a DACT protein, or a functional fragment thereof, in the cell. Also provided is a pharmaceutical composition that comprises a compound of general formula (I), wherein A is CH or N, R1, R4 and R5 are independent from each other H, an aliphatic group, an alicyclic group, an aromatic group, an arylaliphatic group, and an arylalicyclic group comprising 0 - 3 heteroatoms. The heteroatoms may be N, O, S, or Si. R4 and R5 may optionally be linked so as to define an aliphatic hydrocarbyl bridge. R2 is H or a halogen such as F, Cl, Br or L. R3 is H, F, Cl or an aliphatic or arylaliphatic group that includes 1 - 8 main chain carbon atoms and 0 - 3 heteroatoms. The pharmaceutical composition also comprises a histone deacetylase inhibitor..