(cis-cyclohexane-1,3-diyl)-di-acetic acid diethyl ester | 108666-72-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (cis-cyclohexane-1,3-diyl)-di-acetic acid diethyl ester
• 英文别名: (cis-Cyclohexan-1,3-diyl)-di-essigsaeure-diaethylester；Cis-cyclohexane-1,3-diacetic acid diethyl ester；ethyl 2-[(1R,3S)-3-(2-ethoxy-2-oxoethyl)cyclohexyl]acetate
• CAS: 108666-72-4
• 化学式: C₁₄H₂₄O₄
• 分子量: 256.342
• InChiKey: KXRYGMLWOIMEKM-TXEJJXNPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (cis-cyclohexane-1,3-diyl)-di-acetic acid diethyl ester 、 sodium;hydride 、 在 乙酸乙酯 、 Brine 作用下， 以 乙二醇二甲醚 为溶剂， 反应 16.0h， 以to give 3-oxo-bicyclo[3.3.1]nonane-2-carboxylic acid ethyl ester QV which的产率得到3-Oxo-bicyclo[3.3.1]nonane-2-carboxylic acid ethyl ester
  参考文献：
  名称：

  Substituted-Quinoxaline-Type Piperidine Compounds and the Uses Thereof

  摘要：

  本发明涉及取代喹喔啉型哌啶化合物、包含有效量取代喹喔啉型哌啶化合物的组合物以及治疗或预防某种疾病（如疼痛）的方法，包括向需要治疗的动物施用有效量取代喹喔啉型哌啶化合物。

  公开号：

  US20100216726A1
• 作为产物：
  描述：

  diethyl 2,2'-(1,3-phenylene)diacetate 在 溶剂黄146 、 铂 作用下， 生成 (cis-cyclohexane-1,3-diyl)-di-acetic acid diethyl ester
  参考文献：
  名称：

  Theoretical foundations for sound's use in multimedia instruction to enhance learning

  摘要：

  Recent technological advances now snake possible the full integration of sound in instructional software. Sounds may gain and focus learner attention, reduce distracting stimuli, and make learning more engaging. In addition, they may help learners condense, elaborate on, and organize details, highlighting interconnections among new pieces of information and making connections to preexisting knowledge. Thus, sound may hold great promise for moderating acquisition, processing, and retrieval "noise" in instructional software. Unfortunately, interface and instructional design guides almost completely ignore sound, and research suggests many promising instructional uses remain largely unexplored. This paper explores information-processing and communication theoretical foundations for sound's systematic use in the instructional communication system and proposes a framework for a program of research on instructional software's use of sound.

  DOI：

  10.1007/bf02504912

文献信息

• SUBSTITUTED-QUINOXALINE-TYPE PIPERIDINE COMPOUNDS AND THE USES THEREOF
  申请人：Purdue Pharma L.P.

  公开号：US20150141643A1

  公开（公告）日：2015-05-21

  The invention relates to Substituted-Quinoxaline-Type Piperidine Compounds, compositions comprising an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound.

  该发明涉及取代喹喔啉型哌啶化合物，包括一种有效量的取代喹喔啉型哌啶化合物的组合物以及治疗或预防疾病的方法，例如疼痛，通过向需要治疗的动物施用一种有效量的取代喹喔啉型哌啶化合物。
• Substituted-quinoxaline-type piperidine compounds and the uses thereof
  申请人：Fuchino Kouki

  公开号：US08846929B2

  公开（公告）日：2014-09-30

  The invention relates to Substituted-Quinoxaline-Type Piperidine Compounds, compositions comprising an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound.

  本发明涉及替代喹啉型哌啶化合物，包括含有有效量的替代喹啉型哌啶化合物的组合物，以及治疗或预防疾病的方法，例如疼痛，通过向需要的动物施用有效量的替代喹啉型哌啶化合物。
• Substituted-quinoxaline-type-piperidine compounds and the uses thereof
  申请人：Purdue Pharma LP

  公开号：EP2433935A1

  公开（公告）日：2012-03-28

  The invention relates to Substituted-Quinoxaline-Type Piperidine Compounds of Formula (I) and Formula (II), compositions comprising an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound.

  本发明涉及式（I）和式（II）的取代喹喔啉型哌啶化合物、包含有效量的取代喹喔啉型哌啶化合物的组合物，以及治疗或预防疼痛等疾病的方法，包括向有需要的动物施用有效量的取代喹喔啉型哌啶化合物。
• Substituted-quinoxaline-type bridged-piperidine compounds and the uses thereof
  申请人：Purdue Pharma L.P.

  公开号：EP2537844A1

  公开（公告）日：2012-12-26

  The invention relates to Substituted-Quinoxaline-Type Bridged-Piperidine Compounds, compositions comprising an effective amount of a Substituted-Quinoxaline-Type Bridged-Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted-Quinoxaline-Type Bridged-Piperidine Compound.

  本发明涉及取代喹喔啉型桥接哌啶化合物、包含有效量的取代喹喔啉型桥接哌啶化合物的组合物，以及治疗或预防疼痛等疾病的方法，包括向有需要的动物施用有效量的取代喹喔啉型桥接哌啶化合物。
• PIPERIDINE INTERMEDIATES
  申请人：Purdue Pharma L.P.

  公开号：EP3564240A1

  公开（公告）日：2019-11-06

  The invention relates to intermediates A3 and A4 for making Substituted-Quinoxaline-Type Piperidine Compounds.

  本发明涉及用于制造取代喹喔啉型哌啶化合物的中间体 A3 和 A4。